AI Article Synopsis
- Recurrence of bladder cancer is linked to the proliferation of drug-resistant cells, particularly through mechanisms involving drug efflux.
- Previous studies have highlighted the FOXM1 gene as a critical factor in this process, where inhibiting FOXM1 reduces drug efflux and enhances the effectiveness of Doxorubicin.
- The study identifies the ABCG2 gene, associated with drug efflux, as a target regulated by FOXM1, indicating that targeting both FOXM1 and ABCG2 could improve treatment strategies for bladder cancer.
Article Abstract
Recurrence is a serious problem in patients with bladder cancer. The hypothesis for recurrence was that the proliferation of drug-resistant cells was reported, and this study focused on drug resistance due to drug efflux. Previous studies have identified FOXM1 as the key gene for recurrence. We found that FOXM1 inhibition decreased drug efflux activity and increased sensitivity to Doxorubicin. Therefore, we examined whether the expression of ABC transporter gene related to drug efflux is regulated by FOXM1. As a result, ABCG2, one of the genes involved in drug efflux, has been identified as a new target for FOXM1. We also demonstrated direct transcriptional regulation of ABCG2 by FOXM1 using ChIP assay. Consequently, in the presence of the drug, FOXM1 is proposed to directly activate ABCG2 to increase the drug efflux activation and drug resistance, thereby involving chemoresistance of bladder cancer cells. Therefore, we suggest that FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer. [BMB Reports 2018; 51(2): 98-103].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836564 | PMC |
| http://dx.doi.org/10.5483/bmbrep.2018.51.2.222 | DOI Listing |
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