AI Article Synopsis
- The study investigates the levels of PTEN and BCL-2 proteins and mRNAs in 80 acute myeloid leukemia (AML) patients to understand their significance in the disease.
- Results show that PTEN levels are significantly lower and BCL-2 levels are significantly higher in newly diagnosed and relapsed AML patients compared to those in remission and healthy controls.
- The study concludes that PTEN and BCL-2 play a role in AML progression and could be used as biomarkers for assessing treatment effectiveness.
Article Abstract
Objective: To explore the expression of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and B-cell lymphoma/leukemia-2 (BCL-2) in acute myeloid leukemia (AML) and its significance.
Methods: The expression levels of PTEN and BCL-2 mRNA and protein in bone marrow samples from 80 AML patients including 56 de novo patients, 16 patients in remission, 8 relapsed patients and 30 cases of non-hematologic diseases (as control) were detected by real-time PCR and Western blot, respectively, and the relationship between PTEN and BCL-2 expression and clinical pathological parameter was analyzed.
Results: The expression levels of both mRNA and protein of PTEN in newly diagnosed AML group and relapse group were significantly lower than those in the control and remission group (P<0.01). The expression levels of both mRNA and protein of BCL-2 in newly diagnosed group and relapse group were significantly higher than those in the control and remission group (P<0.01). The mRNA expression of PTEN and BCL-2 was did not related with the age, sex and white blood count in AML patients. The expression levels of PTEN negatively correlated with expression BCL-2 with AML(r=-0.432, r=-0.569).
Conclusion: PTEN and BCL-2 participate in the occurrence and development of AML, and may be used as indicators for the evaluation of chemotheraeutic efficacy.
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| http://dx.doi.org/10.7534/j.issn.1009-2137.2018.01.020 | DOI Listing |
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