AI Article Synopsis
- The study evaluated whether changes in drain amylase values, WBC counts, or CRP levels can predict clinically significant postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy.
- One hundred thirty patients were analyzed for these markers on postoperative days (POD) 1, 3, and 5, with a focus on 75 patients who met the criteria for ISGPF grade A by POD 3.
- Key findings indicated that a decrease in drain amylase value to one-third of its level on POD 3 and a lack of improvement in CRP levels were significant risk factors for developing more severe grades of POPF (B and C).
Article Abstract
To diagnose postoperative pancreatic fistula(POPF)after pancreaticoduodenectomy(PD)during early post operative days, we evaluatedwhether a change in drain amylase value(DAV), WBC value, or CRP value predicted clinically significant POPF. One hundred thirty patients underwent substomach preserving PD(SSPPD)from 2005 to 2016 in our institution andwe examinedDAV, WBC, andCRP values at POD 1, 3, and 5. Seventy-five patients(57.7%)were equivalent to ISGPF grade A at POD 3.We analyzedthese 75 cases by following 5 factors(DAV at POD 3>1,500 U/L, DAV at POD 5>1,000 U/L,WBC value at POD 5≤9,000/mL, DAV of POD 5 decreased to 1/3 from DAV of POD 3, CRP value not improved≥50%from POD 3 to 5) andwere concernedwith the crisis of the grade B/C POPF at final diagnosis after POD 5. In conclusion, DAV of POD 5 decreased to 1/3 from DAV of POD 3, andthe CRP value having not improved(≥50%from POD 3 to 5)were significant risk factors for POPF grade B andC by Cox proportional hazard models.
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Article Synopsis
- The study evaluated whether changes in drain amylase values, WBC counts, or CRP levels can predict clinically significant postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy.
- One hundred thirty patients were analyzed for these markers on postoperative days (POD) 1, 3, and 5, with a focus on 75 patients who met the criteria for ISGPF grade A by POD 3.
- Key findings indicated that a decrease in drain amylase value to one-third of its level on POD 3 and a lack of improvement in CRP levels were significant risk factors for developing more severe grades of POPF (B and C).
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