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Unraveling the potential mechanism and prognostic value of pentose phosphate pathway in hepatocellular carcinoma: a comprehensive analysis integrating bulk transcriptomics and single-cell sequencing data.
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Institute of Infectious Diseases, Guangdong Province, Guangzhou Eighth People's Hospital, Guangzhou Medical University, 8 Huaying Road, Baiyun District, Guangzhou, 510440, China.
Hepatocellular carcinoma (HCC) remains a malignant and life-threatening tumor with an extremely poor prognosis, posing a significant global health challenge. Despite the continuous emergence of novel therapeutic agents, patients exhibit substantial heterogeneity in their responses to anti-tumor drugs and overall prognosis. The pentose phosphate pathway (PPP) is highly activated in various tumor cells and plays a pivotal role in tumor metabolic reprogramming.
View Article and Find Full Text PDFAmorphous/Crystalline Urchin-Like TiO SERS Platform for Selective Recognition and Efficient Identification of Glutathione.
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Ningbo Institute of Materials Technology and Engineering, CAS, Chinese Academy of Science, Ningbo, 315201, China.
Glutathione serves as a common biomarkers in tumor diagnosis and treatment. The levels of its intracellular concentration permit detailed investigation of the tumor microenvironment. However, low polarization and weak Raman scattering cross-section make direct and indirect Raman detection challenging.
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Department of Electrical and Computer Systems Engineering, Monash University, Melbourne, VIC 3800, Australia.
Conventional endoscopy is limited in its ability to examine the small bowel and perform long-term monitoring due to the risk of infection and tissue perforation. Wireless Capsule Endoscopy (WCE) is a painless and non-invasive method of examining the body's internal organs using a small camera that is swallowed like a pill. The existing active locomotion technologies do not have a practical localization system to control the capsule's movement within the body.
View Article and Find Full Text PDFDeep BiLSTM Attention Model for Spatial and Temporal Anomaly Detection in Video Surveillance.
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Department of Information Technology, Quaid e Awam University, Nawabshah 67450, Pakistan.
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View Article and Find Full Text PDFThree-Dimensional Reconstruction of Road Structural Defects Using GPR Investigation and Back-Projection Algorithm.
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Department of Roadway Engineering, School of Transportation, Southeast University, Nanjing 211189, China.
Ground-Penetrating Radar (GPR) has demonstrated significant advantages in the non-destructive detection of road structural defects due to its speed, safety, and efficiency. This paper proposes a three-dimensional (3D) reconstruction method for GPR images, integrating the back-projection (BP) imaging algorithm to accurately determine the size, location, and other parameters of road structural defects. Initially, GPR detection images were preprocessed, including direct wave removal and wavelet denoising, followed by the application of the BP algorithm to effectively restore the defect's location and size.
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