The objective of this study was to investigate the presence of obstructive sleep apnoea (OSA) among patients awaiting bariatric surgery and to evaluate if a change in symptoms and clinical measurements of OSA was seen one year after bariatric surgery. Methods: Patients awaiting bariatric surgery in the Region of Southern Denmark were invited to participate in an OSA examination during a 15-month period (2012-2013) using the Embletta device for cardiorespiratory monitoring before and one year after bariatric surgery. The Apnoea-Hypopnoea Index (AHI), weight, BMI and the Epworth Sleepiness Score (ESS) were measured prior to and one year after surgery. Results: A total of 56 patients were enrolled in the study, and 59% were found with OSA (AHI ≥ 5). Thirty-six patients were eligible for examination one year post-operatively. Twelve of these patients did not have OSA (AHI < 5) either at inclusion or at re-examination. In the remaining 24 patients with OSA, the BMI dropped from 44.4 prior to surgery to 30.8 kg/m2 one year after surgery (p < 0.01). Mean AHI decreased from 12.8 prior to surgery to 3.7 one year after surgery (p < 0.01). There was no effect of weight reduction on the ESS. Conclusions: A statistically significant reduction in AHI was seen in patients with OSA one year after surgery. No statistical differences were observed for ESS. Funding: This study was funded by "Fonden for Læge-videnskabelig Forskning m.v. ved sygehusene i Region Syd" and by "Edith og Vagn Hedegaard Jensen fond". Trial registration: ClinGov (ID: S-20120004jln).
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Gynecol Oncol
January 2025
Departments of Internal Medicine and Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States of America; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States of America.
Purpose: We observed that the tumor microenvironment (TME) in metastatic epithelial ovarian cancer (EOC) and in other solid tumors can reprogram normal neutrophils to acquire a complement-dependent suppressor phenotype characterized by inhibition of stimulated T cell activation. This study aims to evaluate whether serum markers of neutrophil activation and complement at diagnosis of EOC would be associated with clinical outcomes.
Experimental Design: We conducted a two-center prospective study of patients with newly diagnosed EOC (N = 188).
Emerg Microbes Infect
January 2025
Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province 518112, China.
() commonly induces refractory infection due to its multidrug-resistant nature. To date, there have been no reports on the application of phage treatment for infection. This study was conducted to explore the feasibility of phage application in treating refractory infection by collaborating with a 59-year-old male patient with a pulmonary infection of multidrug-resistant Our experiments included three domains: ) selection of the appropriate phage, ) verification of the efficacy and safety of the selected phage, ) confirmation of phage-bacteria interactions.
View Article and Find Full Text PDFEur J Orthod
December 2024
Department of General Surgery and Medical-Surgical Specialties, Section of Orthodontics, University of Catania, Policlinico Universitario 'Gaspare Rodolico-San Marco', Via Santa Sofia 78, 95123, Catania, Italy.
Background/objectives: Evidence suggests nasal airflow resistance reduces after rapid maxillary expansion (RME). However, the medium-term effects of RME on upper airway (UA) airflow characteristics when normal craniofacial development is considered are still unclear. This retrospective cohort study used computer fluid dynamics (CFD) to evaluate the medium-term changes in the UA airflow (pressure and velocity) after RME in two distinct age-based cohorts.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Objective: To provide an updated evaluation of clinical effectiveness and sequelae of maxillomandibular advancement surgery in obstructive sleep apnea.
Data Sources: PubMed, Scopus, CINAHL.
Review Methods: Included studies described patients with obstructive sleep apnea that completed maxillomandibular advancement with any reported sequelae.
Otolaryngol Head Neck Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Objective: Margin distance is a significant prognosticator in oral cavity cancer but its role in HPV-related oropharyngeal squamous cell carcinoma [HPV(+)OPSCC] remains unclear. Here, we investigate the impact of margin distance on locoregional recurrence in HPV(+)OPSCC.
Study Design: This is a retrospective cohort study of surgically treated HPV(+)OPSCC patients.
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