Aim: To evaluate the association of (), genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.
Methods: Fasted dyspeptic adults (18-70 years) referred for an upper digestive endoscopy were enrolled in this cross-sectional study. Height and weight were assessed for body mass index (BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzyme-linked immunosorbent assay. C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and DNA amplification and genotyping. Data analysis was performed using χ, Mann-Whitney , Kruskal-Wallis tests, Spearman's correlation and linear regression.
Results: One hundred and sixty-three patients (40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent prevalence was 53.4% (95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/mL (IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/mL (IQR 253.8-547.8)] ( = 0.025), even after adjusting for BMI and gender ( = 0.03). Ghrelin levels tended to be lower in patients carrying positive strains both in the antrum and the corpus; however, differences with those carrying negative strains did not reach statistical significance ( = 0.50 and = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin ( = 0.04), independently of status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/mL (0.80-4.85) 1.84 ng/mL (0.50-5.09), ( = 0.51)].
Conclusion: infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in -positive patients.
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| http://dx.doi.org/10.3748/wjg.v24.i3.397 | DOI Listing |
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