AI Article Synopsis

  • Non-small cell lung cancer has many special cells called fibroblastic stromal cells (FSCs) which are important in how the tumor grows.
  • Scientists are trying to figure out if different types of FSCs help or hurt the tumor.
  • They found that one specific type of FSC, which makes a molecule called CCL19, helps attract immune cells to fight the cancer, and removing these FSCs makes the cancer grow faster.

Article Abstract

Background: A particular characteristic of non-small cell lung cancer is the composition of the tumor microenvironment with a very high proportion of fibroblastic stromal cells (FSCs).

Objective: Lapses in our basic knowledge of fibroblast phenotype and function in the tumor microenvironment make it difficult to define whether FSC subsets exist that exhibit either tumor-promoting or tumor-suppressive properties.

Methods: We used gene expression profiling of lung versus tumor FSCs from patients with non-small cell lung cancer. Moreover, CCL19-expressing FSCs were studied in transgenic mouse models by using a lung cancer metastasis model.

Results: CCL19 mRNA expression in human tumor FSCs correlates with immune cell infiltration and intratumoral accumulation of CD8 T cells. Mechanistic dissection in murine lung carcinoma models revealed that CCL19-expressing FSCs form perivascular niches to promote accumulation of CD8 T cells in the tumor. Targeted ablation of CCL19-expressing tumor FSCs reduced immune cell recruitment and resulted in unleashed tumor growth.

Conclusion: These data suggest that a distinct population of CCL19-producing FSCs fosters the development of an immune-stimulating intratumoral niche for immune cells to control cancer growth.

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http://dx.doi.org/10.1016/j.jaci.2017.12.998DOI Listing

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