Particularities of the management and the treatment in a rare sepsis with Candida tropicalis of a Collodion baby: Case report.

Rationale: Collodion baby is a rare autosomal recessive disorder. It can be the first expression of some forms of ichthyosis.

Patient Concerns: The authors present the case of a newborn diagnosed with severe Collodion baby syndrome who required prolonged hospitalization in the intensive care unit because of infectious complications like the fungal sepsis and other bacterial superinfections.

Diagnoses: The case has many diagnostic and therapeutic particularities and management difficulties. Skin culture, dermatological and genetic exam were required.

Interventions: The treatment required multidisciplinary involvement: neonatologist, pediatrician, geneticist, dermatologist, psychologist, ophthalmologist, audiologist.

Outcomes: The evolution during hospitalization was slowly favorable, but later, after a few months, it developed some complications.

Lessons: In our case, skin injuries, total parenteral nutrition, aggressive and prolonged antibiotic therapy, intravenous devices, high hospitalization duration were risk factors for colonization and sepsis with fungi, especially in the neonatal period, sometimes with severe evolution and prognosis.