AI Article Synopsis
- A number of studies point to the IL-13 gene's role in asthma susceptibility, with inconsistent findings for the +2044G/A and +1923C/T polymorphisms among Asian populations.
- Meta-analysis of data from multiple studies shows a significant association between the IL-13 +2044G/A polymorphism and asthma, especially in Asian adults and children.
- More research is needed with larger sample sizes to fully understand these relationships, as the +1923C/T polymorphism did not show a strong link to age or atopy within Asian subgroups.
Article Abstract
A number of studies have reported that the interleukin 13 (IL-13) gene is associated with asthma susceptibility. However, the reported relationships between the +2044G/A and +1923C/T polymorphisms and asthma susceptibility are inconsistent, especially in Asian adults and children with atopic status. Meta-analysis was used to analyze combined data.The +2044G/A and +1923C/T polymorphisms were investigated using data from 18 and 11 studies, respectively. The results suggested that there was an association between asthma and the IL-13 +2044G/A polymorphisms: odds ratio (OR) 1.34, 95% confidence interval (CI) 1.03-1.75 for AA versus GG + GA and +1923C/T; OR 1.50, 95% CI 1.26-1.78 for TT versus CC; and OR 1.15, 95% CI 1.10-1.21 for TC versus CC. The subgroup meta-analysis demonstrated that IL-13 +2044G/A polymorphisms are associated with asthma: OR 1.47, 95% CI 1.06-2.04 for AA versus GG + GA and +1923C/T; OR 1.70, 95% CI 1.26-2.30 for TT versus CC; and OR 1.27, 95% CI 1.03-1.56 for TC versus CC. In particular, IL-13 +2044G/A polymorphisms are specifically associated with Asian ethnicity in both adults and children with atopic status. However, the 1923C/T polymorphisms were not significantly associated with age group or atopic status within the Asian subgroups. Further investigation using larger samples and meta-analysis is required. No publication bias was detected.This meta-analysis indicates that the IL13 +2044G/A and +1923C/T polymorphisms are risk factors for asthma, especially among Asians.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758167 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000009203 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of +1923C > T, -1112C > T and +2044A > G Polymorphisms in IL-13 Gene with Susceptibility to Pediatric Asthma: A Systematic Review and Meta-Analysis.
Fetal Pediatr Pathol
April 2022
Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Previous studies have provided conflicting evidence implicating the IL-13 polymorphism and pediatric asthma. Thus, we performed a meta-analysis to combine and analyze the available studies to provide more accurate conclusions. A comprehensive retrieval in PubMed, EMBASE, Web of Science, and CNKI was performed up to February 05, 2020.
View Article and Find Full Text PDFInterleukin-13 +2044 G/A and +1923C/T polymorphisms are associated with asthma susceptibility in Asians: A meta-analysis.
Medicine (Baltimore)
December 2017
Department of Intensive Care Unit, The First People's Hospital of Changde City, Changde, Hunan Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, China.
Article Synopsis
- A number of studies point to the IL-13 gene's role in asthma susceptibility, with inconsistent findings for the +2044G/A and +1923C/T polymorphisms among Asian populations.
- Meta-analysis of data from multiple studies shows a significant association between the IL-13 +2044G/A polymorphism and asthma, especially in Asian adults and children.
- More research is needed with larger sample sizes to fully understand these relationships, as the +1923C/T polymorphism did not show a strong link to age or atopy within Asian subgroups.
[Expression of serum interleukin-13 and significance of gene polymorphism on the patients with bronchiectasis in acute exacerbation period].
Zhonghua Yi Xue Za Zhi
January 2017
Department of Respiratory Medicine, Fujian Provincial Hospital, Fujian Provincial Medical College, Fujian Medical University, Fuzhou 350001, China.
To explore the expression of serum interleukin-13 (IL-13) and significance of its gene polymorphism on the patients with acute exacerbation of bronchiectasis in acute exacerbation period. Forty-three patients with bronchiectasis in acute exacerbation period admitted into the respiratory ward of Fujian Provincial Hospital from December, 2014 to March, 2016 were included as bronchiectasis group. Thirty-three healthy controls from normal people of health examination were included as control group during the corresponding period.
View Article and Find Full Text PDFAssociation between IL-13 +1923C/T polymorphism and asthma risk: a meta-analysis based on 26 case-control studies.
Biosci Rep
February 2017
Department of Respiratory Medicine, Weifang People's Hospital, Weifang, Shandong, China
Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin-13 (IL-13) is a central regulator of allergic inflammation. The purpose of the present study was to estimate the relationship between IL-13 +1923C/T polymorphism and asthma susceptibility.
View Article and Find Full Text PDFInterleukin-13 +1923C/T polymorphism is associated with asthma risk: a meta-analysis.
Biomed Res Int
December 2013
Department of Intensive Care Medicine, No. 411 Hospital of PLA, Shanghai 200080, China.
There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. We performed this study to assess the association by the method of meta-analysis. A systematic search current to October 16, 2012, was conducted using PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) and identified ten studies comprising 13698 cases and 38209 controls.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!