AI Article Synopsis
- - An 11-year-old boy with previously good health experienced a 2-week period of nausea and vomiting, followed by jaundice and severe liver failure.
- - Extensive tests for liver disease, toxins, metabolic disorders, and infections returned negative results, except for the detection of human herpesvirus 6B in his liver.
- - The boy successfully received a liver transplant and is doing well post-operation, showing no complications related to the herpesvirus.
Article Abstract
A previously healthy 11-year-old Caucasian boy presented with a 2-week history of nonspecific symptoms of nausea and nonbilious, nonbloody emesis. He developed significant jaundice and hepatic encephalopathy within 1 week of beginning symptoms and was discovered to have fulminant liver failure. Extensive work-ups for underlying etiologies included serologic evaluation for underlying chronic liver diseases, toxicology screening, inborn errors of metabolism, and infectious diseases. The results of the entire assessment were negative except for human herpesvirus 6B, which was detected in the liver by quantitative real-time polymerase chain reaction and immunohistochemical analysis. The patient underwent ABO-compatible liver transplantation and has had clinically stable health, with no evidence to date of complications associated with HHV-6 or other members of the herpesvirus family.
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| http://dx.doi.org/10.1093/labmed/lmx088 | DOI Listing |
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