AI Article Synopsis
- The study examined the cytoprotective effects of bioaccessible fractions from Navel and Cara Cara oranges, and Clementine mandarins on Caco-2 cells exposed to oxidative stress.
- Results showed that the bioaccessible fractions helped maintain cell viability and reduced lipid peroxidation, although fresh mandarin samples didn't quite reach control levels.
- The findings suggest that these fruit pulps can protect cells from oxidative damage by improving cell cycle progression and lowering harmful reactive oxygen species (ROS).
Article Abstract
Fruit pulps from Navel (N) and Cara Cara (CC) oranges, and Clementine mandarin freshly harvested (M) and refrigerated stored (M12) were used to evaluate the cytoprotective effect of their bioaccessible fractions (BF) against HO-induced oxidative stress in Caco-2 cells. BF of samples preserved viability vs. HO treated cells, reaching values similar to controls. Lipid peroxidation was reduced to levels of control cells, but M did not reach control values. ROS and mitochondrial membrane potential changes (Δψ) values were reduced compared with HO treated cells, but without achieving control levels. A significant reduction in cell proportions in G1 phase and a significant increase in sub-G1 phase (apoptosis) of cell cycle was shown in HO treated cells, and BF allowed a recovery close to control levels. Thus, BF of samples protect the cells from oxidative stress by preserving cell viability, mitochondrial membrane potential and correct cell cycle progression, and diminishing lipid peroxidation and ROS.
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| http://dx.doi.org/10.1016/j.foodres.2017.10.066 | DOI Listing |
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