In this work, we report on biodegradable eumelanin-FeO hybrid nanoparticles (euMel-FeO NPs) for multiple imaging-assisted local photothermolysis. The euMel-FeO NPs are rationally prepared via a facile one-step co-precipitation method in the aqueous phase in the presence of eumelanin. The obtained NPs exhibited high stability and aqueous dispersity. euMel-FeO NPs could provide T-weighted magnetic resonance (MR) and photoacoustic (PA) imaging contrast enhancement prior to the treatment, due to their high r relaxivity that was determined to be 245.88 mM s (a value higher than those for other commercially available iron oxide NPs) and good PA signal intensity. Besides, with effective NIR absorbance, the euMel-FeO NPs promoted an effective photothermolysis treatment in an experimental mouse model of cancer. Cytotoxicity and in vivo histological examination demonstrated no appreciable toxicity. Our work suggests that euMel-FeO NPs could be proposed as a potential class of theranostic nanoplatform with multiple imaging modalities for cancer therapy.
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