EBV-CTL immunotherapy targets EBV antigens expressed by tumor cells in PTLD. Data on outcome of EBV-CTL in pSOT patients are limited. The aim of the study is to describe our experience with allogeneic, third-party EBV-CTL for the treatment of PTLD in pSOT patients in a single tertiary center. Retrospective review was performed of all pSOT patients who received EBV-CTL for PTLD. PTLD was diagnosed using World Health Organization histologic criteria. EBV-CTLs were derived from human leukocyte antigen-typed, EBV-seropositive third-party donors, and cryopreserved and maintained by an accredited national blood transfusion service. Ten patients received EBV-CTL for histologically proven PTLD from 1999 to 2016 following liver (n=5), combined intestinal/liver (n=4), and liver/kidney (n=1) transplantation. PTLD occurred at median age of 40 months (range: 12-144) and median post-transplant interval of 8 months (range: 2-107). Seven had monomorphic, two had polymorphic, and one had Hodgkin-type PTLD. All were of B-cell origin and EBV-positive on histology. EBV-CTL achieved an overall remission rate of 80% (8 of 10). Transient adverse effects included fever, tachycardia, and vomiting. None developed graft-versus-host disease or opportunistic infections. EBV-CTL is an effective treatment for PTLD in pSOT patients, with good remission rate and minimal toxicity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/petr.13133 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Primary segmental omental torsion, mimicking acute appendicitis.
J Med Life
January 2024
Colorectal and Digestive Surgery Unit, Beaujon Hospital, Clichy, France.
Primary segmental omental torsion (PSOT) is a very rare cause of acute abdominal pain, and it may often imitate the clinical picture of acute appendicitis. In instances of acute abdominal pain without anorexia, nausea, and vomiting, omental torsion should be included in the differential diagnosis. Any misdiagnosis may lead to major complications such as intraabdominal abscesses and adhesions.
View Article and Find Full Text PDFBurkitt lymphoma after solid-organ transplant: Treatment and outcomes in the paediatric PTLD collaborative.
Br J Haematol
February 2023
Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Utah, Salt Lake City, Utah, USA.
Article Synopsis
- - PSOT-BL, a rare and aggressive form of cancer in children post-organ transplantation, was studied in 35 patients across 14 hospitals in the U.S., with a median age of diagnosis at 8 years, mostly occurring over 2 years after transplant.
- - The most commonly transplanted organs were the heart and liver, and despite the severity of the disease, patients did not experience graft loss or treatment-related deaths.
- - Various treatment regimens were employed, showing a 3-year event-free survival rate of 66.2% and overall survival rate of 88%, indicating that intensive treatments for PSOT-BL can achieve outcomes similar to those in healthy children with Burkitt lymphoma.
Peripheral squamous odontogenic tumor masquerading as oral squamous cell carcinoma in an elderly female patient: A rare entity.
J Family Med Prim Care
June 2022
Department of Oral Pathology, RUHS College of Dental Sciences, Jaipur, Rajasthan, India.
Squamous odontogenic tumor is a rare epithelial odontogenic tumor. Only a few cases have been reported in the literature, out of which central cases occurring within the jawbones are more common, and very rarely peripheral cases have been reported. Here, we report a rare case of a peripheral squamous odontogenic tumor occurring in the left lower gingivobuccal sulcus region in a 63-year-old female patient and presented as a firm and fibrotic swelling clinically.
View Article and Find Full Text PDFComparison of regional analgesia techniques for pleurodesis pain in pediatric patients.
Paediatr Anaesth
October 2020
Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard School of Medicine, Boston, MA, USA.
Background: Mechanical pleurodesis can prevent recurrence of spontaneous pneumothorax but is associated with significant postoperative pain. Adequate pain control is not only beneficial for patient comfort but also critical for mobilization and pulmonary recovery. Thoracic epidural catheters and paravertebral blocks have been used to alleviate pain after thoracoscopic surgery.
View Article and Find Full Text PDFBariatric Surgery in Prior Solid Organ Transplantation Patients: Is Race a Predictor of Adverse Outcomes?
Obes Surg
November 2020
Department of Clinical Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.
Purpose: Metabolic and bariatric surgery (MBS) is increasingly performed in patients with previous solid organ transplantation (PSOT). In addition, controversy remains about whether racial disparity in outcomes following MBS exists. Therefore, the aim of this analysis was to determine if race independently predicts outcomes in MBS patients with PSOT.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!