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Clinical Outcomes and Molecular Profiling of Pancreatic Acinar Cell Carcinoma: A Retrospective Study.
JCO Precis Oncol
January 2025
Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ.
Purpose: Pancreatic acinar cell carcinoma (PACC) is a rare and aggressive form of pancreatic cancer that originates in the acinar cells of the exocrine pancreas. In this study, we aimed to investigate the clinical and molecular characteristics of patients with PACC at our institution.
Methods: This was a retrospective study of patients with PACC seen at Mayo Clinic between 2002 and 2023.
Clinical usefulness of four-dimensional dynamic ventilation CT for borderline resectable locally advanced esophageal cancer.
Jpn J Radiol
October 2024
Department of Diagnostic Radiology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
Purpose: This study aimed to evaluate the clinical significance of four-dimensional dynamic ventilation CT (4DCT) for assessing resectability in borderline resectable locally advanced esophageal cancer (BR-LAEC) and confirmed the pathological validity of the 4DCT results in surgery without prior treatment.
Materials And Methods: We retrospectively reviewed 128 patients (107 men; median age, 68 [range, 43-89] years) diagnosed with BR-LAEC on initial conventional CT (i-CT). These patients were initially classified into three categories: BR1 (closer to resectable), BR2 (resectability not assessable), or BR3 (closer to unresectable).
'IHPBA-APHPBA clinical practice guidelines': international Delphi consensus recommendations for gallbladder cancer.
HPB (Oxford)
November 2024
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, USA.
Article Synopsis
- The Delphi consensus study, conducted by IHPBA-APHPBA, aimed to create global practice guidelines for managing gallbladder cancer (GBC).
- Experts from 17 countries participated in a four-round consensus process, where 68 clinical questions were posed and a consensus was reached if more than 75% of participants agreed.
- The study achieved consensus on 92.6% of the questions, covering important aspects of GBC management, but noted that further research is needed on unresolved issues such as the definitions of borderline resectable and locally advanced GBC.
A qualitative study on the disease coping experiences of pancreatic cancer patients and their spouses.
Sci Rep
August 2024
Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Cancer affects patients as well as their spouses. Patients and their spouses use different strategies to cope with cancer and the associated burden. This study aimed to gain a deeper and more differentiated understanding of support systems for patients and their spouses.
View Article and Find Full Text PDFUpdate on management of pancreatic cancer: a literature review.
Chin Clin Oncol
June 2024
Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.
Background And Objective: Pancreatic cancer is an aggressive malignancy with high mortality. At the time of diagnosis, majority of patients (80-90%) present with either locally advanced unresectable disease or metastatic disease. Even after curative resection, the recurrence rate remains quite high.
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