AI Article Synopsis
- Significant differences exist in the expression of the urokinase plasminogen activator (uPA) system between cancer tissues and normal tissues, but its effectiveness as a prognostic biomarker for non-small cell lung cancer (NSCLC) is still uncertain.
- A systematic review and meta-analysis of 11 studies involving 937 NSCLC patients showed that increased levels of uPA and PAI-1 did not significantly correlate with poor overall survival (OS), while reduced PAI-2 also had no significant association with OS.
- In contrast, higher expression of the uPA receptor (uPAR) was significantly linked to poor OS, suggesting that uPAR could serve as a promising clinical biomarker for assessing NSCLC prognosis and guiding targeted treatments.
Article Abstract
Current relevant research suggests there are significant differences between the expression of the urokinase plasminogen activator (uPA) system in cancer tissues and in normal tissues. However, the potential effectiveness of the uPA system as a prognostic biomarker of non-small cell lung cancer (NSCLC) remains unclear. In the present study, a systematic review and meta-analysis were performed to evaluate the relevance of the uPA system in the prognosis of patients with NSCLC. Using the PubMed, EMBASE, Web of Science and Cochrane Library databases, data from relevant academic journal articles were extracted and subjected to analysis. Associations between expression profiles pertaining to the uPA system and the overall survival (OS) of patients with NSCLC were analyzed. The study incorporated data from 11 independent journal articles and these reports included a total of 937 patients with NSCLC. The meta-analysis results revealed that increased expression of urokinase plasminogen activator (uPA) and PA inhibitor type 1 (PAI-1) exhibited no significant association with poor OS [hazard ratio (HR)-uPA=1.07 (0.87-1.31), P=0.53; HR-PAI-1=1.02 (0.63-1.65), P=0.94]. Similarly, reduced expression of PAI type 2 (PAI-2) did not significantly correlate with poor OS [HR-PAI-2=1.58 (0.64-3.90); P=0.32]. Notably, however, a significant association was observed between increased expression levels of uPA receptor (uPAR) and poor OS for NSCLC [HR-uPAR=1.50 (1.04-2.15); P=0.03]. Therefore, the expression of uPAR in the uPA system of patients with NSCLC could be used as a novel clinical biomarker to evaluate the prognosis of NSCLC. The utilization of this biomarker may provide a platform for the further development of targeted drugs for the treatment of NSCLC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769288 | PMC |
| http://dx.doi.org/10.3892/mco.2017.1484 | DOI Listing |
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