The safety and efficacy of twice-daily applications of alclometasone dipropionate cream 0.05% were evaluated in 39 children with eczema during a three-week open study. Early-morning plasma cortisol levels were monitored at weekly intervals (visits 1, 2, and 3) for six children. For the remaining 33 children, levels were measured at visits 1 and 2 and two weeks later, at visit 4. Improvement in signs and symptoms of erythema, induration, and pruritus and a global response to therapy were determined weekly. Plasma cortisol levels remained within the acceptable normal range of 7 to 25 micrograms/100 ml throughout the study in all 39 children. At the conclusion of treatment, a favorable global response--complete clearing of monitored signs and symptoms--was observed in 28 (72%) children, and marked or moderate improvement was recorded for seven (18%) children.
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January 2024
Department of Biology and Biotechnologies "Charles Darwin", Sapienza University of Rome, Rome, Italy.
J Drugs Dermatol
September 2020
Epidermal growth factor (EGFR)-inhibitors have emerged as the primary therapy in advanced solid tumor malignancies because of improvement in survival with overall favorable side effect profile. However, 50–90% of patients treated with EGFR-inhibitors develop a follicular or acneiform rash, which can be symptomatic and source of psychosocial distress, negatively impacting quality of life. As this acneiform rash is a well-recognized cutaneous toxicity of EGFR-inhibitors, a treatment algorithm has been proposed for management based on severity.
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Department of Dermatology and Cutaneous Surgery, Jackson Health System/University of Miami Miller School of Medicine, Miami, Florida.
The vast majority of atopic dermatitis follows a mild, chronic relapsing course. In this article, we highlight the art and practice of treating atopic dermatitis based upon a foundation of maintenance care and a ladder of therapy that can teach patients and their families how to best tailor their pharmaceutical options to optimize the management of their disease.
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August 2013
Department of Oncology, Ryhov County Hospital, Jönköping, Sweden.
Background And Purpose: The aim was to investigate whether treatment with potent local steroids can reduce signs and symptoms of acute radiation dermatitis in breast cancer patients undergoing adjuvant radiotherapy (RT) compared to emollient creams.
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Pediatr Ann
January 2013
Department of Pediatrics, Rush University Medical Center, Chicago, IL 60611, USA.
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