Antihyperglycemic and antidyslipidemic activity of -based diet in alloxan-induced diabetic rats.

This study was aimed at investigating the antihyperglycemic and antidyslipidemic activity of -based diets in alloxan-induced diabetic mellitus rats. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg b.w) in 48 randomly selected rats. The rats were randomly grouped into four as follows: normal rats fed -based diet, diabetic control rats fed -based diet, diabetic rats fed -based diet and administered metformin (14.2 mg/kg body weight) orally per day, and diabetic rats fed -based diet. Body weight and fasting blood glucose level were monitored, on 28th days the rats were sacrificed, liver was excised. Thereafter, the hyperglycemic and dyslipidemic statii of the induced diabetic animals were determined. The -based diet significantly (<.05) reversed the levels of fasting blood glucose, with significant (<.05) increase in insulin and glycogen concentrations. The diet also increased the activity of hexokinase with significant reduction (<.05) in glucose-6-phosphatase and fructose-1-6-diphosphatase activities. -based diet demonstrated significant reduction (<.05) in cholesterol, triacylglycerol (TG), very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and significant increase (<.05) in high-density lipoprotein (HDL) compared with those of diabetic control group. Also, -based diet significantly (<.05) reversed the activities of aspartate aminotransferase and alanine aminotransferase when compared with diabetic control animals. The consumption of this diet may be useful in ameliorating hyperglycemia and dyslipidemia in diabetes mellitus patients.