Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.
Objective: Scouting special and beneficial side effects of selegiline treatment.
Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks' treatment.
Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.
Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.
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http://dx.doi.org/10.2174/1874104501711010138 | DOI Listing |
Int J Pharm
January 2025
Department of Pharmaceutics, Bharti Vidyapeeth Deemed to be University, Poona College of Pharmacy, Erandwane, Pune 411038, Maharashtra, India. Electronic address:
Depression is a common mental condition causing depressed mood and loss of pleasure. The primary treatment approach for the management of depression consists of the use of selegiline (MAO-B) inhibitor compound. The present work aimed to develop and optimize selegiline-loaded nanostructured lipid carriers for transdermal application, utilizing a 2 full factorial design approach.
View Article and Find Full Text PDFAm J Stem Cells
December 2024
Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences Khorramabad, Iran.
Development and maintenance of the nervous system are governed by a scheduled cell death mechanism known as apoptosis. Very much how neurons survive and function depends on the degree of death in differentiating pseudo-neuronal cells produced from neural stem cells. Different inducers can affect the degree of death in these cells: hormones, medicines, growth factors, and others.
View Article and Find Full Text PDFJ Med Chem
January 2025
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
Monoamine oxidase-B (MAO-B), predominantly exists on the outer mitochondrial membrane of astrocytes, serves as a crucial biomarker for reactive astrocytes during neuroinflammatory responses and various neurodegenerative diseases. In this study, we synthesized a series of fluorinated coumarin derivatives and evaluated their structure-activity relationship and subtype selectivity for MAO-B. Following this, the preclinical bioevaluation containing positron emission tomography (PET) imaging and autoradiography studies led to the identification of the novel PET tracer, [F], which demonstrated high affinity for MAO-B (IC = 0.
View Article and Find Full Text PDFNeurology
January 2025
From the Department of Clinical Neurosciences (M.W.K., J.R.S.), University of Calgary, Alberta; Division of Neurology (L.V.K.), Department of Medicine, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario; Department of Medicine (D.W.), University of British Columbia Southern Medical Program, Kelowna; Division of Neurology (T.A.M., M.G.S.), Department of Medicine, University of Ottawa, The Ottawa Hospital Ottawa, Ontario, Canada; Department of Neurology (J.M.), Rijnstate Hospital, Arnhem; Department of Neurology (E.M.M.S., B.U.), MS Center Amsterdam, Amsterdam University Medical Centers, the Netherlands; Section on Statistical Planning and Analysis (A.S.), Department of Neurology, UT Southwestern Medical Center, Dallas; and Department of Biostatistics (G.R.C.), University of Alabama at Birmingham.
Background And Objectives: Disease-modifying treatments (DMTs) are a major unmet need in Parkinson disease (PD). To date, trials investigating DMT candidates in PD most often used a randomized controlled trial (RCT) design. Unfortunately, RCTs to date have not led to a breakthrough, in part because of the large sample sizes and length of follow-up required.
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