Association between gene polymorphism and susceptibility to and prognosis of diffuse large B-cell lymphoma.

Lysosomal protein transmembrane 4β () is an oncogene that is overexpressed in a number of various types of human cancer. There are two known alleles of : and . The present study assessed the association between polymorphisms and the susceptibility to diffuse large B-cell lymphoma (DLBCL) and its prognosis. genotypes were determined using polymerase chain reaction analysis in 164 DLBCL and 350 healthy control cases. The association between polymorphisms and the risk of DLBCL was analyzed using unconditional logistic regression. Differences in patient survival were calculated using Kaplan-Meier analysis. The present study indicated no significant differences (P>0.05) in the frequency of alleles between DLBCL cases (26.5%) and controls (24.1%). The risk of DLBCL was slightly increased in cases with the genotype [odds ratio (OR)=1.160; 95% confidence interval (CI)=0.781-1.724] or the genotype (OR=1.446; 95% CI=0.648-3.227) compared with those with the genotype. There was no significant association between the presence of the allele and overall survival (OS) and disease-free survival (DFS) in patients with DLBCL (P=0.399 and 0.520, respectively). However, there was a tendency for patients with and International Prognostic Index (IPI) score 3-5 to have longer OS and DFS (P=0.126 and 0.109, respectively). These findings suggest that genetic polymorphisms of is not a risk factor for the development of DLBCL, but the allele may a better prognostic indicator in patients with IPI score 3-5 in DLBCL.