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Structure and Functional Characteristics of Novel Polyurethane/Ferrite Nanocomposites with Antioxidant Properties and Improved Biocompatibility for Vascular Graft Development.
Polymers (Basel)
January 2025
Department of Biochemistry, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
Novel ferrite/polyurethane nanocomposites were synthesized using the in situ polymerization method after the addition of different spinel nanoferrite particles (copper, zinc, and copper-zinc) and examined as potential coatings for medical devices and implants in vascular tissue engineering. The influence of the nanoferrite type on the structure and functional characteristics of the polyurethane composites was investigated by FTIR, SWAXS, AFM, TGA, DSC, nanoindentation, swelling behavior, water contact angle, and water absorption measurements. Biocompatibility was evaluated by examining the cytotoxicity and adhesion of human endothelial cells and fibroblasts onto prepared composites and performing a protein adsorption test.
View Article and Find Full Text PDFUtilisation of the Innovative [18F]-Labelled Radiotracer [18F]-BIBD-071 Within HR+ Breast Cancer Xenograft Mouse Models.
Pharmaceuticals (Basel)
January 2025
Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100071, China.
Aromatase plays a crucial role in the conversion of androgens to oestrogens and is often overexpressed in hormone-dependent tumours, particularly breast cancer. [18F]BIBD-071, which has excellent binding affinity for aromatase and good pharmacokinetics, has potential for the diagnosis and treatment of aromatase-related diseases. The MCF-7 cell line, which is hormone receptor-positive (HR+), was used in the assessment of the novel [18F]-labelled radiotracer [18F]BIBD-071 via positron emission tomography (PET) imaging of an HR+ breast cancer xenograft model.
View Article and Find Full Text PDFComplex Left Main Trifurcation: A Case Study of Successful Treatment.
J Clin Med
January 2025
Cardiology Department, "Victor Babes" University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania.
True trifurcation disease of the left main coronary artery is a rare situation encountered in clinical practice. To date, there is no evidence for a standardized strategy of percutaneous coronary intervention in this type of lesion. This article describes a novel three-stent strategy using a combination of Triple-Kissing Balloon Crush in both of the side branches.
View Article and Find Full Text PDFSandwiched Strut Allografts with Stem Retention to Treat Fragile Periprosthetic Femoral Fractures: A Case Report.
Medicina (Kaunas)
January 2025
Department of Orthopaedic Surgery, Chosun University Hospital, 365 Pilmundae-ro, Dong-gu, Gwangju 61453, Republic of Korea.
Managing periprosthetic femoral fractures is challenging, particularly in osteoporotic patients with fragile bones. Revision with a long stem is commonly considered but may fail to provide adequate fixation and stability in fragile bones. A novel approach using sandwiched strut allografts and controlled bone crushing with robust cable fixation can offer mechanical support and provide secondary stability to the loosened femoral stem and can be considered a treatment option for low-demand patients.
View Article and Find Full Text PDFEmerging Strategies in Cartilage Repair and Joint Preservation.
Medicina (Kaunas)
December 2024
Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, 2 Eftimie Murgu, 300041 Timisoara, Romania.
Cartilage repair remains a critical challenge in orthopaedic medicine due to the tissue's limited self-healing ability, contributing to degenerative joint conditions such as osteoarthritis (OA). In response, regenerative medicine has developed advanced therapeutic strategies, including cell-based therapies, gene editing, and bioengineered scaffolds, to promote cartilage regeneration and restore joint function. This narrative review aims to explore the latest developments in cartilage repair techniques, focusing on mesenchymal stem cell (MSC) therapy, gene-based interventions, and biomaterial innovations.
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