The timely management of diabetic ketoacidosis (DKA) is essential to avoid lengthy hospitalizations and poor clinical outcomes. There is often an absence of ownership for glycemic management in hospitalized patients, most notably in those with a diagnosis other than diabetes. Evidence supports the use of evidence-based DKA protocols. The purpose of this project was to determine whether utilization of an evidence-based order set versus an individualized provider approach for the treatment and management of DKA decreases resolution time and occurrences of hypoglycemia and improves clinical outcomes. Preintervention and postintervention retrospective reviews of the electronic medical record of 150 nonpregnant adult patients diagnosed with DKA allowed retrieval of relevant outcome data. Multiple events provided an intensive orientation and development of health care professionals for a systems approach to utilization of the evidence-based order set. Implementation of the institutionally approved evidence-based order set affirmed anticipated outcomes. Results showed improvements in the (a) total length of stay, (b) arrival to intravenous fluid time, (c) intravenous insulin initiation to discontinuation (resolution) time, (d) arrival to subcutaneous insulin administration time, (e) time from initial to sequential laboratory testing, (f) use of a basal, prandial, and correction insulin approach (physiological mimic), and (g) the incidence of hypoglycemia. Outcomes substantiate the importance and need for maintaining an evidence-based and systems approach for the management of DKA.
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Chem Biodivers
January 2025
University of Shanghai for Science and Technology, Department of chemistry, No. 334, Jungong Road, Yangpu District, Shanghai, 200093, Shanghai, CHINA.
The main protease (Mpro) of SARS-CoV-2 is an evolutionarily conserved drug discovery target. The present study mainly focused on chemoinformatics computational methods to investigate the efficacy of our newly designed trifluoromethyl-1,3,4-oxadiazole amide derivatives as SARS-CoV-2 Mpro inhibitors. Drug-likeness ADMET analysis, molecular docking simulation, density functional theory (DFT) and molecular dynamics simulation methods were included.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K.
Ferroelectric nematic (N) liquid crystals combine liquid-like fluidity and orientational order of conventional nematics with macroscopic electric polarization comparable in magnitude to solid-state ferroelectric materials. Here, we present a systematic study of twenty-seven homologous materials with various fluorination patterns, giving new insight into the molecular origins of spontaneous polar ordering in fluid ferroelectric nematics. Beyond our initial expectations, we find the highest stability of the N phase to be in materials with specific fluorination patterns rather than the maximal fluorination, which might be expected based on simple models.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
Key Laboratory of Organic Integrated Circuit, Tianjin Key Laboratory of Molecular Optoelectronic Sciences & Ministry of Education, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China.
The exploitation of high-performance third-order nonlinear optical (NLO) materials that have a favorable optical limit (OL) threshold is essential due to a rise in the application of ultra-intense lasers. In this study, a Cu-based MOF (denoted as Cu-bpy) was synthesized, and its third-order NLO and OL properties were investigated using the Z-scan technique with the nanosecond laser pulse excitation set at 532 nm. The Cu-bpy exhibits a typical rate of reverse saturable absorption (RSA) with a third-order nonlinear absorption coefficient of 100 cm GW and a favorable OL threshold of 0.
View Article and Find Full Text PDFTrop Med Infect Dis
December 2024
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Background: Onchocerciasis, or river blindness, is one of the neglected tropical diseases (NTDs) that the WHO has set out to eliminate. To reach this elimination target, a number of challenges must be met, and the essential measures set out in the road map for NTDs 2021-2030 must be implemented. More than 99% of infected people live in 31 countries in sub-Saharan Africa.
View Article and Find Full Text PDFJ Intell
January 2025
School of Labor and Employment Relations, University of Illinois Urbana-Champaign, Champaign, IL 61820, USA.
Complex problem solving (CPS) refers to a set of higher-order capacities that allow an individual to interact with a dynamic environment and solve complex problems. The purpose of this study was to develop and validate Sokoban, a game-based assessment of the planning-execution stage of the CPS framework proposed by PISA 2012. The psychometric properties of this instrument were examined in a large sample of Chinese students ( = 1145) ranging from elementary to tertiary education.
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