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Intralesional botulinum toxin-A injection for the treatment of multiple eccrine hidrocystomas. | LitMetric

Intralesional botulinum toxin-A injection for the treatment of multiple eccrine hidrocystomas.

J Cosmet Laser Ther

a Skin Research Center, Shahid Beheshti University of Medical Sciences , Shohada Tajrish Hospital, Tehran , Iran.

Published: October 2018

AI Article Synopsis

  • Multiple eccrine hidrocystomas (MEH) are benign cystic lesions on the face that can cause cosmetic concerns, and botulinum toxin-A has been explored as a treatment due to its antiperspirant properties.
  • A study involving 20 patients evaluated the safety and effectiveness of intralesional botulinum toxin-A injections, where over 75% of the lesions resolved without scarring.
  • The treatment was found to be simple, well-tolerated, and potentially a first-line option for patients unresponsive to other treatments, despite some minor side effects that resolved on their own.

Article Abstract

Background: Multiple eccrine hidrocystomas (MEH) are benign cystic lesions of the sweat gland ducts. They are characterized by translucent, skin-colored or bluish dome-shaped papules on the face, causing cosmetic concern. Recently, botulinum toxin-A, because of its antiperspirant properties, has been used to treat facial MEH. However, there are only some case reports in the literature.

Objective: Here, we conducted a prospective study to assess the efficacy and safety of intralesional injection of botulinum toxin-A (Dysport) for the treatment of MEH.

Material And Methods: Twenty patients (3 men and 17 women), aged from 31 to 75 years old, participated in this study. A 300 unit vial of botulinum toxin-A (Dysport, Ipsenn Biopharm, United Kingdom) was diluted with 4 ml of saline solution without preservative to achieve a concentration of 7.5U/.1 ml. Up to 1.5 unit of botulinum toxin was injected intradermally at the base of each lesion to raise a visible wheal. The patients were evaluated 7 days later, and any clinical changes or adverse effects were recorded.

Results: In all patients, more than 75% of eccrine hidrocystoma lesions resolved without any scaring. The result sustained for 2-5 months. In two patients mild smile asymmetry and in one patient lagophthalmos were noted approximately 5-7 days after injection that gradually resolved in 3 weeks.

Conclusion: Intralesional botulinum toxin-A for treatment of multiple hidrocystomas is a simple and well-tolerated procedure. It is accompanied by excellent results, a good postoperative course, and no risk of scarring. It can be considered in patients who did not respond to other treatment or even as the first line therapy.

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Source
http://dx.doi.org/10.1080/14764172.2017.1406608DOI Listing

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