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[VIPoma : a rare etiology of diarrhea with hypokalemia]. | LitMetric

[VIPoma : a rare etiology of diarrhea with hypokalemia].

Rev Med Suisse

Service de médecine interne, Hôpital de la Tour, avenue J.-D. Maillard 3, 1217 Genève.

Published: January 2018

VIPoma or Verner Morrison syndrome is a very rare disease with an incidence rate of 1 case per 10 000 000 person-years. It is a neuroendocrine tumor issue from β-pancreatic islets leading to profuse diarrhea, hypokalemia and gastric achlorydria due to secretion of vasoactive intestinal polypeptide (VIP) hormone. Diagnosis is based on histology of tumor and the dosage of VIP in a blood sample. Somatostatin analog is a simple and efficient treatment for diarrhea. Curative treatment with surgery could be proposed for a localized disease. For disseminated disease, there are different treatments and a multimodal assessment that should be discussed in a multidisciplinary team might be curative.

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