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Impact of Hydro-Alcoholic Bark Extract on Diabetic Wound Healing: A Topical Approach.
Int J Low Extrem Wounds
December 2024
Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India.
Purpose: The current study was aimed to evaluate the potential of against diabetic foot ulcer, where the wound healing is impaired and susceptible to infection.
Methods: The effects of hydroalcoholic bark extract (MOHE) on different parameters influencing diabetic wound healing were comprehensively investigated including: anti-inflammatory effects, antibacterial properties, antioxidant activity, anti-diabetic properties, and fibroblast proliferation and migration. Furthermore, in vivo studies were conducted in diabetic rats and Zebrafish to investigate the topical effects of MOHE on wound healing.
Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression.
Biomolecules
March 2024
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68106, USA.
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4.
View Article and Find Full Text PDFPassenger lymphocyte syndrome following minor ABO-mismatched liver transplantation.
BMJ Case Rep
March 2024
Internal Medicine, University of Florida, Gainesville, Florida, USA
Passenger lymphocyte syndrome is an immunologic disorder observed in solid organ and haematopoietic stem cell transplantation in which B lymphocytes within a donor graft are transferred to the recipient and subsequently produce circulating antibodies against host red blood cell antigens. The syndrome is most likely to occur in minor ABO blood group mismatched or Rh incompatible transplantation. Although generally mild and self-limited, the resulting haemolytic burden has the potential to increase the risk of infection, graft failure and death.
View Article and Find Full Text PDFInfrared Spectroscopy for Rapid Triage of Cancer Using Blood Derivatives: A Reality Check.
Anal Chem
January 2024
Department of Biological Sciences and Engineering, Indian Institute of Technology Palakkad, Palakkad 678623, India.
Infrared (IR) spectroscopy of serum/plasma represents an alluring molecular diagnostic tool, especially for cancer, as it can provide a molecular fingerprint of clinical samples based on vibrational modes of chemical bonds. However, despite the superior performance, the routine adoption of this technique for clinical settings has remained elusive. This is due to the potential confounding factors that are often overlooked and pose a significant barrier to clinical translation.
View Article and Find Full Text PDFAlcohol-induced hormonal and metabolic alterations in plasma and erythrocytes-a gender-based study.
Toxicol Mech Methods
May 2024
Department of Biochemistry, REVA University, Bangalore. Karnataka, India.
Purpose: This study aimed to understand the gender-specific alcohol-induced biochemical changes and TBARS association with the endocrine system.
Methods: Human male and female subjects ranging from 35 ± 10 years old with an 8-10-year drinking history were included in the study.
Results: The results demonstrated that testosterone levels were lower in male alcoholics and higher in female alcoholics, as well as higher estrogen and cortisol levels in both genders.
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