Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionc0un34t5cs2n5l82fmtkl1f1et8o8ccf): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 197
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3145
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
The methanol extract of suspension cultures were subjected to column chromatography to identify potential inhibitors of β-secretase, which is a major factor in Alzheimer's disease development. Two new -methylisoflavones boeravinone T () and U () were isolated with three knowns boeravinone B (), J () and X (). The half-maximal inhibitory concentration (IC) values of compounds - were 18.29, 8.57, 7.87, 12.02 and 5.30 μM, respectively. The most potent , non-competitively inhibited β-secretase [inhibition constant (K) = 3.79 μM]. Compounds - did not inhibit other proteases such as chymotrypsin, trypsin and elastase at concentrations up to 1 mM, indicating that they were relatively specific inhibitors of β-secretase. A free hydroxyl group at C-3 position of the -methylisoflavone skeleton appeared to be responsible for the stronger inhibitory activity against β-secretase.
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Source |
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http://dx.doi.org/10.1080/14786419.2018.1431637 | DOI Listing |
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