Takes a Multi-Target Approach to Achieve Junction Breach.

Front Cell Infect Microbiol

Centre National de la Recherche Scientifique ERL5261, CEA BIG-BCI, Institut National de la Santé et de la Recherche Médicale UMR1036, Université Grenoble Alpes, Grenoble, France.

Published: December 2018

is an opportunistic pathogen which uses a number of strategies to cross epithelial and endothelial barriers at cell-cell junctions. In this review, we describe how the coordinated actions of 's virulence factors trigger various molecular mechanisms to disarm the junctional gate responsible for tissue integrity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770805PMC
http://dx.doi.org/10.3389/fcimb.2017.00532DOI Listing

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