Under Pressure: A New Role for CD11c Myeloid Cells in Hypertension.

Hypertension

From the Center for Cardiology-Cardiology I (S.K., P.W.) and Center for Thrombosis and Hemostasis Mainz (S.K., P.W.), University Medical Center Mainz, Germany; and German Center for Cardiovascular Research-Partner Site Rhine-Main, Germany (P.W.).

Published: April 2018

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10216DOI Listing

Publication Analysis

Top Keywords

pressure role
4
role cd11c
4
cd11c myeloid
4
myeloid cells
4
cells hypertension
4
pressure
1
cd11c
1
myeloid
1
cells
1
hypertension
1

Similar Publications

Pollinator species richness and abundance across diverse habitat-types on Terceira Island (Azores, Portugal).

Biodivers Data J

January 2025

IUCN SSC Monitoring Specialist Group, Angra do Heroísmo, Azores, Portugal IUCN SSC Monitoring Specialist Group Angra do Heroísmo, Azores Portugal.

Background: Azorean biodiversity is relatively well-known following important scientific contributions during the last three decades. These have set a comprehensive species checklist for the Archipelago, improved significantly the knowledge on species abundance, ecology and distribution and have contributed to define priorities for conservation management and scientific research. Nevertheless, despite these efforts, a key functional group - the pollinators - remains poorly known in Azores, including their occurrence in different habitat-types and islands.

View Article and Find Full Text PDF

Mechanochemistry and mechanocatalysis are gaining increasing attention as environmentally friendly chemical processes because of their solvent-free nature and scalability. Significant effort has been devoted for studying continuum-scale phenomena in mechanochemistry, such as temperature and pressure gradients, but the atomic-scale mechanisms remain relatively unexplored. In this work, we focus on the mechanochemical reduction of MoO as a case study.

View Article and Find Full Text PDF

C3AR1 as a target for preeclampsia: from bioinformatics and network pharmacology to experimental validation.

BMC Pregnancy Childbirth

January 2025

Obstetrics and Gynecology Center, Department of Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.

Background: Preeclampsia, characterized by hypertension and proteinuria during pregnancy, poses significant risks to both mother and fetus. The complement system's aberrant activation, notably the C3AR1, is important to the pathogenesis of preeclampsia, although the precise mechanisms are not fully understood.

Materials And Methods: Utilizing the Comparative Toxicogenomics Database (CTD) and Molecular Signatures Database (MSigDB), we identified complement system targets associated with preeclampsia and environmental pollutants.

View Article and Find Full Text PDF

Climate change policies are driving the oil and gas industry to explore CO injection for carbon dioxide storage in reservoirs. In the United States, a substantial portion of oil production relies on CO-enhanced-oil-recovery (CO-EOR), demonstrating a growing interest in using CO to address various production challenges like condensate mitigation, pressure maintenance, and enhancing productivity in tight reservoirs. CO injection introduces gases like natural gas and N, either pre-existing or as impurities in the injected CO gas.

View Article and Find Full Text PDF

Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition.

Sci Rep

January 2025

Department of Pharmacology and Experimental Therapeutics; MS 1015, College of Pharmacy and Pharmaceutical Sciences, The University of Toledo, Health Education Building; Room 282E, 3000 Arlington Ave, Toledo, OH, 43614, USA.

We previously demonstrated that the inability of primary endothelial cilia to sense fluid shear stress can lead to nitric oxide (NO) deficiency and cause hypertension (HTN). Decreased biosynthesis of NO contributes to cerebral amyloid angiopathy in Alzheimer's disease (AD) patients through increased deposition of amyloid beta (Aβ). However, the molecular mechanisms underlying the pathogenesis of HTN and AD are incompletely understood.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!