Development of newer drug carrier systems by the researchers has resulted in numerous breakthroughs in the development and manufacturing of ocular products. The ocular bioavailability of drugs at the posterior segment of the eye is a challenging task in the present scenario. Naturally derived macromolecular carriers are widely used to increase the efficacy of ocular drugs. They provide enhanced corneal permeability and retention effect at the surface of cornea for a prolonged period of time. In this regimen the present review focuses towards the major ocular diseases and their prevalence and development of efficient drug carrier systems utilizing various naturally derived macromolecules for improved delivery of drugs to treat ocular diseases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2018.01.120 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Noninfectious Uveitis in Pediatric Rheumatology: Long-term Follow-up at Tertiary Centers.
J Clin Rheumatol
March 2025
From the Department of Pediatric Rheumatology, Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School.
Objectives: Our study aimed to identify potential predictors for additional systemic involvement in patients with noninfectious uveitis, specifically focusing on their demographic, etiological, clinical, and laboratory data features from the pediatric rheumatology perspective.
Methods: Patients with noninfectious uveitis before the age of 18 years and followed up for at least 3 months in 2 tertiary centers of pediatric rheumatology and ophthalmology departments were included in the study. Demographics, etiology, clinical features, laboratory data, and treatments administered were evaluated and compared based on the etiology (idiopathic and systemic disease-related uveitis [SD-U]) and the use of biologic disease-modifying antirheumatic drugs.
Ocular motor cranial neuropathy and risk of thyroid cancer: A Korean population-based study.
PLoS One
March 2025
Department of Ophthalmology, Hallym University School of Medicine, Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea.
This study investigates whether ocular motor cranial neuropathy (OMCN) can predict the onset of thyroid cancer given its association with common cardiovascular risk factors including obesity, diabetes mellitus (DM), hypertension, and dyslipidemia. We conducted a retrospective, nationwide, population-based cohort study utilizing data from the Korean National Health Insurance Service. Individuals comprised those aged ≥ 20 years diagnosed with OMCN between 2010 and 2017.
View Article and Find Full Text PDFThe causal effects of inflammatory bowel disease on its ocular manifestations: A Mendelian randomization study.
PLoS One
March 2025
Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Background: Observational studies have shown that ocular manifestations of inflammatory bowel disease (IBD) are common extraintinal manifestations, among which iridocyclitis, scleritis and episcleritis are the most common. However, whether there is a causal relationship between the two is unclear. The purpose of this study was to evaluate the causality of IBD on ocular manifestations using the mendelian randomization (MR) analysis.
View Article and Find Full Text PDFSafety of intravitreal injections with the mobile laminar airflow device Operio after more than 10.000 injections.
Int Ophthalmol
March 2025
Department of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy.
Purpose: To evaluate the occurrence of complications following intravitreal injections (IVIs) performed in an outpatient clean room (OCR) equipped with the mobile laminar airflow device (LAF) Operio.
Methods: This retrospective study analyzed the data of 10,016 IVIs performed in an OCR from April 2023 to November 2024. All information of each patient was registered, such as diagnosis, drug injected and any occurring complication or adverse events such as endophthalmitis, intraocular inflammation, rhegmatogenous retinal detachment (RRD), vitreous hemorrhages and elevated intraocular pressure.
Th17 Response in Uveitis: A Double-Edged Sword in Ocular Inflammation and Immune Regulation.
Clin Rev Allergy Immunol
March 2025
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Uveitis involves a complex interplay of immune cell infiltration and cytokine imbalances, with Th17 cells playing a central role in this process. Th17 cells contribute to disease pathogenesis by promoting inflammation, recruiting additional immune cells, and directly damaging retinal tissues. This review discusses the current knowledge on therapeutic strategies targeting Th17-related cytokines, including cytokine blockade, small molecule inhibitors, and immunomodulatory approaches.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!