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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29377434</PMID><DateCompleted><Year>2018</Year><Month>10</Month><Day>15</Day></DateCompleted><DateRevised><Year>2018</Year><Month>10</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-4998</ISSN><JournalIssue CitedMedium="Internet"><Volume>74</Volume><Issue>7</Issue><PubDate><Year>2018</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Pest management science</Title><ISOAbbreviation>Pest Manag Sci</ISOAbbreviation></Journal><ArticleTitle>A herbicide structure-activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana.</ArticleTitle><Pagination><StartPage>1558</StartPage><EndPage>1563</EndPage><MedlinePgn>1558-1563</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ps.4872</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">To fight herbicide-resistant weeds, new herbicides are needed; particularly ones with new modes of action. Building on the revelation that many antimalarial drugs are herbicidal, here we focus on the Medicines for Malaria Venture antimalarial lead compound MMV007978 that has herbicidal activity against the model plant Arabidopsis thaliana.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-two variations of the lead compound thiophenyl motif revealed that change was tolerated provided ring size and charge were retained. MMV007978 was active against select monocot and dicot weeds, and physiological profiling indicated that its mode of action is related to germination and cell division. Of interest is the fact that the compound has a profile that is currently not found among known herbicides.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We demonstrate that the antimalarial compound MMV007978 is also herbicidal and that exploiting lead compounds that are often understudied could lead to the identification of interesting herbicidal scaffolds. Further structural investigation of MMV007978 could provide improved herbicidal chemistries with a potential new mode of action. &#xa9; 2018 Society of Chemical Industry.</AbstractText><CopyrightInformation>&#xa9; 2018 Society of Chemical Industry.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Corral</LastName><ForeName>Maxime G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>School of Molecular Sciences, University of Western Australia, Crawley, WA, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leroux</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>School of Molecular Sciences, University of Western Australia, Crawley, WA, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tresch</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>BASF, Ludwigshafen am Rhein, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newton</LastName><ForeName>Trevor</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>BASF, Ludwigshafen am Rhein, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stubbs</LastName><ForeName>Keith A</ForeName><Initials>KA</Initials><Identifier Source="ORCID">0000-0001-6899-402X</Identifier><AffiliationInfo><Affiliation>School of Molecular Sciences, University of Western Australia, Crawley, WA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mylne</LastName><ForeName>Joshua S</ForeName><Initials>JS</Initials><Identifier Source="ORCID">0000-0003-4957-6388</Identifier><AffiliationInfo><Affiliation>School of Molecular Sciences, University of Western Australia, Crawley, WA, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>ARC Centre of Excellence in Plant Energy Biology, University of Western Australia, Crawley, WA, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>03</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Pest Manag Sci</MedlineTA><NlmUniqueID>100898744</NlmUniqueID><ISSNLinking>1526-498X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006540">Herbicides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017360" MajorTopicYN="N">Arabidopsis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006540" MajorTopicYN="N">Herbicides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Arabidopsis thaliana</Keyword><Keyword MajorTopicYN="N">Medicines for Malaria Venture</Keyword><Keyword MajorTopicYN="N">Plasmodium</Keyword><Keyword MajorTopicYN="N">antimalarial</Keyword><Keyword MajorTopicYN="N">herbicide resistance</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>12</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>1</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>1</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>10</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29377434</ArticleId><ArticleId IdType="doi">10.1002/ps.4872</ArticleId></ArticleIdList></PubmedData></PubmedArticle></PubmedArticleSet>