Background: The idea that changes to the host immune system are critical for cancer progression was proposed a century ago and recently regained experimental support.
Results: Herein, the hypothesis that hepatocellular carcinoma (HCC) leaves a molecular signature in the host peripheral immune system was tested by profiling DNA methylation in peripheral blood mononuclear cells (PBMC) and T cells from a discovery cohort ( = 69) of healthy controls, chronic hepatitis, and HCC using Illumina 450K platform and was validated in two validation sets ( = 80 and = 48) using pyrosequencing.
Conclusions: The study reveals a broad signature of hepatocellular carcinoma in PBMC and T cells DNA methylation which discriminates early HCC stage from chronic hepatitis B and C and healthy controls, intensifies with progression of HCC, and is highly enriched in immune function-related genes such as , a current cancer immunotherapy target. These data also support the feasibility of using these profiles for early detection of HCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774119 | PMC |
| http://dx.doi.org/10.1186/s13148-017-0436-1 | DOI Listing |
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