Background: Radiotherapy-induced acute skin reactions are common and an expected effect of radiotherapy. Eczematous eruptions, however, are rarely reported, with disseminated eczema in particular being infrequently seen and likely underrecognized.
Objective: We present a unique case of disseminated vesicular eczema following radiotherapy for ductal carcinoma in situ.
Conclusions: The development of a localized vesicular eruption with subsequent dissemination can occur following radiotherapy. The mechanism of autosensitization is poorly understood but likely involves a cell-mediated immune response. Recognition is important to prevent excessive and inappropriate investigation and treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/1203475418755997 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fish oil and vitamin D in pregnancy for the prevention of early childhood asthma: study protocol for two double-blinded, randomised controlled trials.
BMJ Open
December 2024
Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Gentofte, Denmark.
Introduction: Previous randomised controlled trials (RCTs) have indicated a protective role of pregnancy supplementation with fish oil and high-dose vitamin D, respectively, on offspring asthma, infections and several other disorders in early childhood. However, current evidence is not considered sufficient for recommending these supplements in pregnancy. In two RCTs, we aim to investigate whether these protective effects can be confirmed in larger trials with the goal of changing clinical practice and improving child health.
View Article and Find Full Text PDFSelf-Guided vs Clinician-Guided Online Cognitive Behavioral Therapy for Atopic Dermatitis: A Randomized Clinical Trial.
JAMA Dermatol
December 2024
Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Importance: Clinician-guided online self-help based on cognitive behavioral therapy (CBT) has been shown to be effective at decreasing symptom severity for people with atopic dermatitis (AD). A brief online self-guided CBT intervention could be more cost-effective and allow for easy implementation and broader outreach compared with more comprehensive clinician-guided interventions.
Objective: To investigate whether a brief online self-guided CBT intervention is noninferior to a comprehensive online clinician-guided CBT treatment.
Erythroderma in the elderly.
J Dermatol
November 2024
Department of Dermatology, Fukushima Medical University, Fukushima, Japan.
Erythroderma is the end-stage condition caused by various inflammatory diseases, presenting with widespread generalized coalesced erythema on the trunk and extremities. Erythroderma is not a disease itself, but rather is a symptom expressing erythrodermic condition, which is frequently associated with inguinal lymphadenopathy, chills, and mild fever. The clinical characteristics include sparing the folds of the trunk and extremities (deck-chair sign), and cobblestone-like disseminated grouping prurigo; however, the deck-chair sign is not specific to papulo-erythroderma (Ofuji disease).
View Article and Find Full Text PDFThe antimicrobial protein RNase 7 directly restricts herpes simplex virus infection of human keratinocytes.
J Med Virol
October 2024
Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Article Synopsis
- About 22% of patients with moderate to severe atopic dermatitis have experienced eczema herpeticum, an infection primarily caused by the herpes simplex virus type 1 (HSV-1), potentially due to reduced antimicrobial peptide activity.
- This study found that the antimicrobial protein RNase 7 can limit HSV-1 infection in human skin cells (keratinocytes) by inhibiting gene expression and viral genome replication without relying on added DNA for stimulation.
- RNase 7 acts on intracellular processes of infection rather than affecting how the virus binds to cells, suggesting that its reduced activity in atopic dermatitis may increase the risk of developing eczema herpeticum.
Short-form thymic stromal lymphopoietin (sfTSLP) restricts herpes simplex virus infection of human primary keratinocytes.
J Med Virol
September 2024
Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
Article Synopsis
- Eczema herpeticum (EH) is a severe herpes simplex virus type 1 (HSV-1) infection that commonly affects individuals with atopic dermatitis (AD) and is influenced by genetic, environmental, and immunological factors.
- The study focuses on thymic stromal lymphopoietin (TSLP), which has two forms: a long form primarily linked to type 2 immune responses, and a short form (sfTSLP) known for its anti-inflammatory and antimicrobial effects.
- Results indicate that sfTSLP effectively reduces HSV-1 infection in human primary keratinocytes by lowering virus gene expression and replication, demonstrating significant antiviral properties without needing new protein synthesis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!