Boar seminal plasma and seminal vesicle fluid inhibited mitogen-induced blastic transformation of porcine lymphocytes. Chromatographic separation of seminal vesicle fluid on Sephadex G-100 yielded four fractions. Only the SV-1 fraction displayed significant inhibition of blastic transformation. The results demonstrated that the immunosuppressive factor(s) in seminal plasma is secreted in seminal vesicles. Increased inhibition of blastic transformation of lymphocytes stimulated with pokeweed mitogen indicates that seminal plasma inhibits mainly B lymphocytes. Both seminal plasma and seminal vesicle fluid inhibited unstimulated lymphocytes.
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