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Impaired skeletal muscle oxygenation following allogeneic hematopoietic stem cell transplantation is associated with exercise capacity. | LitMetric

AI Article Synopsis

  • Impaired skeletal muscle oxygenation after allogeneic hematopoietic stem cell transplantation (allo-HSCT) may lead to decreased exercise capacity and altered hemoglobin responses in patients.
  • The study involved observing muscle oxygenation and hemoglobin parameters using near-infrared spectroscopy during exercise in 18 patients before and after they underwent allo-HSCT.
  • Results showed a significant decrease in muscle oxygenation (SmO) after allo-HSCT, while total hemoglobin levels remained unchanged, indicating a connection between reduced muscle oxygenation and lowered exercise capacity.

Article Abstract

Introduction: Impaired skeletal muscle oxygenation potentially contributes to reduced exercise capacity in allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients during early recovery and may explain altered hemoglobin responses to exercise following allo-HSCT. We investigated whether skeletal muscle oxygenation parameters and hemoglobin parameters in the tibialis anterior decreased following allo-HSCT, and whether these results were associated with declines in exercise capacity.

Methods: We used near-infrared spectroscopy during and following a repeated isometric contraction task at 50% of maximal voluntary contraction in 18 patients before and after allo-HSCT.

Results: The rate of decrease in the muscle oxy-hemoglobin saturation (SmO; an index of skeletal muscle oxygenation) was significantly lower after allo-HSCT (P < 0.01). In contrast, total hemoglobin (an index of hemoglobin) was not different after allo-HSCT. Furthermore, SmO during and following exercise was associated with exercise capacity (r = 0.648; P = 0.004 vs. r = 0.632; P = 0.005).

Conclusion: The results of this study reveal that although the peripheral hemoglobin response was not altered by allo-HSCT, skeletal muscle oxygenation was decreased following allo-HSCT. Furthermore, the decrease in skeletal muscle oxygenation was associated with a reduction in exercise capacity.

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Source
http://dx.doi.org/10.1007/s00520-017-4036-6DOI Listing

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