AI Article Synopsis
- The text discusses a yeast-like fungus that can cause serious brain infections (meningoencephalitis) in people with weak immune systems.
- It primarily enters the body through inhalation and can spread to the central nervous system either as individual cells or within immune cells called macrophages.
- The review aims to highlight the importance of biofilm formation by the fungus, especially its ability to thrive in harsh environments, and encourages new research on how these biofilms impact fungal diseases.
Article Abstract
is an encapsulated yeast-like fungus capable of causing life threatening meningoencephalitis in patients with impaired immunity. This microbe primarily infects the host via inhalation but has the ability to disseminate to the central nervous system (CNS) either as a single cell or inside of macrophages. Upon traversing the blood brain barrier, has the capacity to form biofilm-like structures known as cryptococcomas. Hence, we will discuss the elements contributing to biofilm formation including the fungus' ability to survive in the acidic environment of a macrophage phagosome and inside of the CNS. The purpose of this mini-review is to instill fresh interest in understanding the importance of biofilms on fungal pathogenesis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715963 | PMC |
| http://dx.doi.org/10.3390/jof3010010 | DOI Listing |
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