Whole-Genome Sequences of Zika Virus FLR Strains after Passage in Vero or C6/36 Cells.

Lindsey A Moser Lauren M Oldfield Nadia Fedorova Vinita Puri Susmita Shrivastava Paolo Amedeo Richard Isom Lihui Hu Alan Durbin Iara Rocchi Torrey Williams Gene S Tan Reed S Shabman Kristen A Bernard Brett E Pickett

Genome Announc

J. Craig Venter Institute, La Jolla, California, USA

Published: January 2018

The study presents 26 complete genomes of the Zika virus obtained after passaging a specific strain (FLR) in mosquito and mammalian cell lines.
The analyzed genomes exhibit over 99% nucleotide identity among themselves and with the original FLR strain.
This high level of genetic similarity suggests that the passaging process did not significantly alter the virus's genetic makeup.

We report 26 complete genomes of Zika virus (ZIKV) isolated after passaging the Zika virus strain FLR in mosquito (C6/36) and mammalian (Vero) cell lines. The consensus ZIKV genomes we recovered show greater than 99% nucleotide identify with each other and with the FLR strain used as input.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786684	PMC
http://dx.doi.org/10.1128/genomeA.01528-17	DOI Listing

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