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Development and proof-of-concept of a multicenter, patient-centered cancer registry for breast cancer patients with metastatic disease-the "Breast cancer care for patients with metastatic disease" (BRE-4-MED) registry.
Pilot Feasibility Stud
February 2020
2Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany.
Background: Patients with metastatic breast cancer (MBC) are treated with a palliative approach with focus on controlling for disease symptoms and maintaining high quality of life. Information on individual needs of patients and their relatives as well as on treatment patterns in clinical routine care for this specific patient group are lacking or are not routinely documented in established Cancer Registries. Thus, we developed a registry concept specifically adapted for these incurable patients comprising primary and secondary data as well as mobile-health (m-health) data.
View Article and Find Full Text PDFA Constitutive Relationship between Fatigue Limit and Microstructure in Nanostructured Bainitic Steels.
Materials (Basel)
October 2016
Department of Mechanical and Process Engineering Materials Testing (AWP), University of Kaiserslautern, Gottlieb-Daimler-Straße, Kaiserslautern 67663, Germany.
The recently developed nanobainitic steels show high strength as well as high ductility. Although this combination seems to be promising for fatigue design, fatigue properties of nanostructured bainitic steels are often surprisingly low. To improve the fatigue behavior, an understanding of the correlation between the nanobainitic microstructure and the fatigue limit is fundamental.
View Article and Find Full Text PDFHuman ind1, an iron-sulfur cluster assembly factor for respiratory complex I.
Mol Cell Biol
November 2009
Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, 35033 Marburg, Germany.
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a large mitochondrial inner membrane enzyme consisting of 45 subunits and 8 iron-sulfur (Fe/S) clusters. While complex I dysfunction is the most common reason for mitochondrial diseases, the assembly of complex I and its Fe/S cofactors remains elusive. Here, we identify the human mitochondrial P-loop NTPase, designated huInd1, that is critically required for the assembly of complex I.
View Article and Find Full Text PDFHohenheimer Consensus Talk. Oxidative and premature skin ageing.
Exp Dermatol
August 2004
Department of Biological Chemistry and Nutrition, University of Hohenheim, Fruwirthstr. 12, 70593 Stuttgart, Germany.
To elucidate the scientific state of the art with respect to the role of nutrition in skin ageing, nine experts from different disciplines discussed the role of micronutrients on 'oxidative and premature skin ageing'. In this 25th Hohenheim Consensus Meeting, 13 questions were discussed and, based on published valid data, answered by mutual agreement. The consensus answers achieved during the meeting are justified by a scientific background text.
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