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The impact of a secondary, rare, non-pathogenic PKD1 variant on disease progression in autosomal dominant polycystic kidney disease.
J Nephrol
January 2025
Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is caused primarily by pathogenic variants in the PKD1 and PKD2 genes. Although the type of ADPKD variant can influence disease severity, rare, hypomorphic PKD1 variants have also been reported to modify disease severity or cause biallelic ADPKD. This study examines whether rare, additional, potentially protein-altering, non-pathogenic PKD1 variants contribute to ADPKD phenotypic outcomes.
View Article and Find Full Text PDFThe Daily Process of Interpersonal Conflict and Mood among Chinese Adolescents: A Multilevel Moderated Mediation Analysis of Cognitive Appraisal, Social Support and Psychological Capital.
Res Child Adolesc Psychopathol
January 2025
School of Developmental Psychology, Faculty of Psychology, Beijing Normal University, 19 Xinjiekouwai Avenue, Haidian District, Beijing, 100875, China.
A growing body of literature has confirmed the within-person process from interpersonal conflict to adolescent mood on a day-to-day timescale. However, research on how, when and for whom adolescent interpersonal conflict relates to their daily mood is underdeveloped. This study examined whether interpersonal conflict is related to mood through threat appraisal and self-blaming attribution and whether these relationships would be moderated by daily social support and psychological capital.
View Article and Find Full Text PDFPrimary Leiomyosarcoma of the Thyroid.
Head Neck Pathol
January 2025
Department of medical oncology, Habib Bourguiba Hospital, University of Sfax, Sfax, 3029, Tunisia.
Leiomyosarcoma (LMS) is a malignant mesenchymal neoplasm showing smooth muscle differentiation. Primary LMS of the thyroid gland is quite rare, accounting for only 0.014% of cases.
View Article and Find Full Text PDFThe Impact of Racial and Low Socioeconomic Status on the Implementation of Spinal Cord Stimulation for Chronic Pain in the United States.
Curr Pain Headache Rep
January 2025
Department of Physical Medicine & Rehabilitation, Temple University Hospital, Philadelphia, PA, USA.
Objectives: This study aims to review the societal, economic, and racial factors that impact the usage of spinal cord stimulation for chronic pain. Our working hypothesis is that patients of ethnic minority groups or of lower socioeconomic status (SES) status may have lower implantation rates and usage of spinal cord stimulation (SCS).
Materials And Methods: Our study sourced publications from PubMed, Embase, and Cochrane Library on December 21st, 2023 for SCS for the purposes of pain management.
Safe access to laparoscopic cholecystectomy in patients with previous periumbilical incsions: new approach to avoid entry related bowel injury.
Langenbecks Arch Surg
January 2025
Alexandria Main University Hospital, Alexandria, Egypt.
Background: Patients with prior abdominal surgeries are at higher risk of intra-peritoneal adhesions near the trocar entry site, increasing the likelihood of organ injury during laparoscopic cholecystectomy (LC). This study evaluates a novel technique where the epigastric trocar is inserted first, after creating pneumoperitoneum, to allow safe dissection of adhesions under direct vision before placing the umbilical trocar.
Methods: This prospective study included 244 patients with symptomatic uncomplicated gallstone disease and a history of previous abdominal surgeries extending to the umbilicus.
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