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Study on the Efficacy and Safety of Tedizolid in Japanese Patients.
Antibiotics (Basel)
December 2024
Department of Infectious Diseases, St. Luke's International Hospital, Tokyo 104-8560, Japan.
: Tedizolid (TZD), an oxazolidinone, causes fewer adverse events than linezolid (LZD). However, studies on the long-term efficacy and safety of TZD, particularly in patients with hematological malignancies (HMs), remain limited. This study aimed to evaluate the safety of long-term TZD use in Japanese patients, including those with HM.
View Article and Find Full Text PDFOptic and peripheral neuropathy associated with short and prolonged administration of tedizolid: a review.
Expert Rev Anti Infect Ther
January 2025
Alfa Institute of Biomedical Sciences, Athens, Greece.
Introduction: Tedizolid is a novel antibiotic of the class of oxazolidinones. This review evaluates the published literature on the optic and peripheral neuropathy associated with short and prolonged administration of tedizolid.
Areas Covered: A review of published data from 4 databases was conducted, regarding the development of optic and peripheral neuropathy in patients who received tedizolid for short or prolonged duration.
Severe Optic Neuropathy Induced by Very Prolonged Tedizolid as Suppressive Therapy: Description of a Case Report and Implication for Better Assessment.
Open Forum Infect Dis
September 2024
Department of Ophthalmology, Tours University Hospital, TOURS, France.
The long-term tolerability of linezolid is low because of mitochondrial toxicity, whereas tedizolid may represent a better option for suppressive therapy. We report a first presumed case of tedizolid-associated optic neuropathy after a very prolonged (18-month) intake and believe that screening for optic neuropathy should be considered for patients undergoing tedizolid suppression.
View Article and Find Full Text PDFEfficacy and safety of long-term use of tedizolid in disseminated nocardiosis after heart transplantation.
Transpl Infect Dis
February 2024
Infectious Diseases Division, Clínica Universidad de Navarra, Pamplona, Spain.
Oxazolidinone: A promising scaffold for the development of antibacterial drugs.
Eur J Med Chem
March 2023
School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China. Electronic address:
Due to the long-term and widespread use of antibiotics in clinic, the problem of bacterial resistance is increasingly serious, and the development of new drugs to treat drug-resistant bacteria has gradually become the mainstream direction of antibiotic research. The oxazolidinone-containing drugs linezolid, tedizolid phosphate and contezolid have been approved to the market, which are effective against a variety of Gram-positive bacterium infections. Moreover, there are also many antibiotics containing oxazolidinone fragment under clinical investigation that show good pharmacokinetic and pharmacodynamic properties with unique mechanism of action against resistant bacteria.
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