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Integrated Studies on Male Reproductive Toxicity of Decabromodiphenyl Ethane in Zebrafish Spermatozoa , Male Zebrafish , and GC-1 Cells .
Environ Health Perspect
November 2024
Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Background: Legacy brominated flame retardants have been recognized as risky factors leading to declined sperm quality. The widespread utilization of decabromodiphenyl ethane (DBDPE) as a replacement for decabromodiphenyl ether has given rise to considerable concern over its potential risks to reproductive health.
Objectives: The objectives were to quickly determine whether DBDPE affects sperm quality upon exposure, to reveal the reproductive outcomes and underlying molecular mechanisms using an zebrafish model exposed to DBDPE, and to validate the potential impact on DNA damage and energy metabolism balance .
Current computational tools for protein lysine acylation site prediction.
Brief Bioinform
September 2024
Collaborative Innovation Center of Henan Grain Crops, Henan Key Laboratory of Rice Molecular Breeding and High Efficiency Production, College of Agronomy, Henan Agricultural University, Zhengzhou 450046, China.
As a main subtype of post-translational modification (PTM), protein lysine acylations (PLAs) play crucial roles in regulating diverse functions of proteins. With recent advancements in proteomics technology, the identification of PTM is becoming a data-rich field. A large amount of experimentally verified data is urgently required to be translated into valuable biological insights.
View Article and Find Full Text PDFUnraveling the molecular dynamics of biofilms at the air-liquid interface.
Future Microbiol
July 2024
Division of Microbiology, National Center for Toxicological Research, US FDA, Jefferson, AR 72079, USA.
The aim of this study was to probe the dynamics of PA14 air-liquid interface (ALI) biofilms over time through global proteomic analysis. PA14 ALI biofilm samples, collected over 48-144 h, underwent differential expression analysis to identify varying proteins at each time point. A consistent set of 778 proteins was identified, with variable expression over time.
View Article and Find Full Text PDFECOD domain classification of 48 whole proteomes from AlphaFold Structure Database using DPAM2.
PLoS Comput Biol
February 2024
Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
Protein structure prediction has now been deployed widely across several different large protein sets. Large-scale domain annotation of these predictions can aid in the development of biological insights. Using our Evolutionary Classification of Protein Domains (ECOD) from experimental structures as a basis for classification, we describe the detection and cataloging of domains from 48 whole proteomes deposited in the AlphaFold Database.
View Article and Find Full Text PDFSystematic Exploration of Privileged Warheads for Covalent Kinase Drug Discovery.
Pharmaceuticals (Basel)
October 2022
School of Data Science and Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904, USA.
Kinase-targeted drug discovery for cancer therapy has advanced significantly in the last three decades. Currently, diverse kinase inhibitors or degraders have been reported, such as allosteric inhibitors, covalent inhibitors, macrocyclic inhibitors, and PROTAC degraders. Out of these, covalent kinase inhibitors (CKIs) have been attracting attention due to their enhanced selectivity and exceptionally strong affinity.
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