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A blastocyst's implantation potential is linked to its originating oocyte cohort's blastulation rate: evidence for a cohort effect.
Fertil Steril
December 2024
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, California.
Objective: To investigate if blastocysts originating from different follicular cohorts have variable implantation rates, adjusted for oocyte age, morphology, and/or ploidy.
Design: Retrospective cohort.
Setting: Academic center.
Transcriptomic signature of luteinized cumulus cells of oocytes developing to live birth after women received intracytoplasmic sperm injection.
F S Sci
February 2024
Department of Reproductive Endocrinology, University Hospital Zurich, Frauenklinikstrasse, Zurich, Switzerland.
Objective: To compare the transcriptome of human cumulus cells (CCs) from oocytes with different outcomes (pregnancy yes/no, live birth [LB] yes/no), to identify noninvasive biomarkers for oocyte selection as well as new therapeutic targets to increase LB rates from assisted reproductive technologies (ART).
Design: Retrospective observational study.
Settings: This study was conducted at a University Hospital in Switzerland.
Good practice recommendations on add-ons in reproductive medicine†.
Hum Reprod
November 2023
The Fertility Department, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Study Question: Which add-ons are safe and effective to be used in ART treatment?
Summary Answer: Forty-two recommendations were formulated on the use of add-ons in the diagnosis of fertility problems, the IVF laboratory and clinical management of IVF treatment.
What Is Known Already: The innovative nature of ART combined with the extremely high motivation of the patients has opened the door to the wide application of what has become known as 'add-ons' in reproductive medicine. These supplementary options are available to patients in addition to standard fertility procedures, typically incurring an additional cost.
Meeting the demand for fertility services: the present and future of reproductive endocrinology and infertility in the United States.
Fertil Steril
October 2023
National Institutes of Health, National Institute for Child Health and Human Development, Program in Reproductive and Adult Endocrinology, Bethesda, Maryland; Shady Grove Fertility, Washington, District of Columbia; Departments of Obstetrics and Gynecology, Georgetown University and George Washington University, Washington, DC.
The field of reproductive endocrinology and infertility (REI) is at a crossroads; there is a mismatch between demand for reproductive endocrinology, infertility and assisted reproductive technology (ART) services, and availability of care. This document's focus is to provide data justifying the critical need for increased provision of fertility services in the United States now and into the future, offer approaches to rectify the developing physician shortage problem, and suggest a framework for the discussion on how to meet that increase in demand. The Society of REI recommend the following: 1.
View Article and Find Full Text PDFCausal inference indicates that poor responders have similar outcomes with the antagonist protocol compared with flare.
Fertil Steril
August 2023
Alife Health, Inc., Cambridge, Massachusetts. Electronic address:
Objective: To use causal inference to investigate whether the flare or antagonist protocol is better for poor responders going through controlled ovarian stimulation.
Design: A retrospective study.
Setting: Retrieval cycles from the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System.
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