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Phyto-nutraceutical promise of Brassica vegetables in post-genomic era: a comprehensive review.
Planta
December 2024
Institute of Agricultural Sciences, SOA University, Bhubaneswar, 751029, India.
Brassica vegetables are one of the possible solutions to tackle the emerging human diseases and malnutrition due to their rich content of phyto-nutraceutaical compounds. The genomics enabled tools have facilitated the elucidation of molecular regulation, mapping of genes/QTLs governing nutraceutical compounds, and development of nutrient-rich Brassica vegetables. The enriched food products or foods as whole termed as functional foods are intended to provide health benefits.
View Article and Find Full Text PDFRevisiting the genetic architecture of autism spectrum disorders in the genomic era: Insights from East Asian studies.
Curr Opin Neurobiol
November 2024
Department of Neurology, Songjiang Hospital, Songjiang Research Institute, MOE-Shanghai Key Laboratory for Children's Environmental Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- The review explores the genetic basis of Autism Spectrum Disorder (ASD), emphasizing findings from East Asian populations and advancements in genetic research methods like whole-exome and whole-genome sequencing.
- Critical discoveries include the significance of rare de novo variants, which differ from previously recognized common variants, in understanding the genetic landscape of ASD.
- The authors stress the need for large, diverse ASD study cohorts and international collaboration to enhance research and develop effective treatment strategies.
"The Giant Black Elephant with white Tusks stood in a field of Green Grass": Cognitive and brain mechanisms underlying aphantasia.
Conscious Cogn
January 2025
Department of Psychology, The University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:
Aphantasia, a spectrum of inabilities creating and perceiving mental images, is becoming more of a focus in continued research to better understand functions of sensory perception and imagination. Current research on aphantasia is still in an era of exploration to find its underlying neural mechanisms, comorbidities and comparing levels of visual imagery to other cognitive functions. Through a systematic review, this article explores the most influential developments in aphantasia research.
View Article and Find Full Text PDFFGF8-mediated gene regulation affects regional identity in human cerebral organoids.
Elife
November 2024
Univ. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France.
Article Synopsis
- The study investigates how the morphogen FGF8 affects the development of brain-like structures derived from human stem cells, specifically focusing on its role in establishing cellular diversity and regional identities during early brain development.
- FGF8 treatment led to the formation of various brain regions within the organoids, influencing the identity of neural progenitor cells and the ratio of different types of neurons (GABAergic and glutamatergic).
- The research highlights FGF8's critical role in regulating genes linked to neurodevelopmental disorders, suggesting its potential involvement in both healthy brain development and related pathological conditions.
Sentiment analysis of post-COVID-19 health information needs of autism spectrum disorder community: insights from social media discussions.
Front Psychiatry
October 2024
Nobel International Business School, Accra, Ghana.
Objective: This study explores the health information needs of individuals with autism spectrum disorder (ASD) and their caregivers in the post-COVID-19 era by analyzing discussions from Reddit, a popular social media platform.
Methods: Utilizing a mixed-method approach that integrates qualitative content analysis with quantitative sentiment analysis, we analyzed user-generated content from the "r/autism" subreddit to identify recurring themes and sentiments.
Results: The qualitative analysis uncovered key themes, including symptoms, diagnostic challenges, caregiver experiences, treatment options, and stigma, reflecting the diverse concerns within the ASD community.
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