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Masquelet technique combined with concentrated growth factors for the reconstruction of rabbit mandibular marginal bone defect.
Clin Oral Investig
January 2025
Fujian Key Laboratory of Oral Diseases & Stomatological Key lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian Province, 350002, China.
Objective: Both the Masquelet technique (MT) and concentrated growth factors (CGF) reduce early graft loss and improve bone regeneration. This study aims to explore the efficacy of combining MT with CGF for mandibular defect repair by characterizing the induced membrane and assessing in vivo osteogenesis.
Materials And Methods: Three experimental groups were compared: negative control (NC), MT, and Masquelet combined with CGF (MTC).
Comparison of two plates and screw osteosynthesis configurations in a rat model of critical sized femoral defects to reduce implant related failures.
Sci Rep
January 2025
U1008 - Advanced Drug Delivery Systems and Biomaterials, Univ. Lille, INSERM, CHU Lille, Lille, F-59000, France.
This study aimed to compare the failure rates of two different sizes of plates and screws to stabilize critical-sized (7 mm) femoral defects in male Sprague‒Dawley rats (aged 10 weeks). Femoral defects were stabilized with either a 4-hole plate (length 29 mm, thickness 1 mm, 10 rats, Group 1) and 4 cortical screws (diameter 2 mm) or with a 6-hole plate (length 30 mm, thickness 0.6 mm, 9 rats, Group 2) and 4 cortical screws (diameter 1.
View Article and Find Full Text PDFMasquelet Inspired in Vivo Engineered Extracellular Matrix as Functional Periosteum for Bone Defect Repair and Reconstruction.
Adv Healthc Mater
January 2025
Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.
The Masquelet technique that combines a foreign body reaction (FBR)-induced vascularized tissue membrane with staged bone grafting for reconstruction of segmental bone defect has gained wide attention in Orthopedic surgery. The success of Masquelet hinges on its ability to promote formation of a "periosteum-like" FBR-induced membrane at the bone defect site. Inspired by Masquelet's technique, here a novel approach is devised to create periosteum mimetics from decellularized extracellular matrix (dECM), engineered in vivo through FBR, for reconstruction of segmental bone defects.
View Article and Find Full Text PDFInduced membrane technique for aseptic recalcitrant nonunion of the femur and tibia: Bone union and deformity correction outcomes.
J Clin Orthop Trauma
February 2025
Orthopaedic and Trauma Surgery Department, Hospital de Alta Complejidad Cuenca Alta, RP6 Km 92.5 PC 1814, Cañuelas, Buenos Aires, Argentina.
Introduction: Aseptic recalcitrant nonunion (ARNU) of the femur and tibia is an entity in which the absence of bony union, misalignment, and limb length discrepancies (LLD) coexist. Currently, the management of these cases lacks consensus. This study aimed to describe the bone union rate and deformity correction outcomes in patients with ARNU of the femur or tibia treated with the Induced Membrane Technique (IMT).
View Article and Find Full Text PDFClinical Observations of the Effectiveness of the Masquelet Induced Membrane Technique in the Treatment of Critical Long-Bone Defects of the Lower and Upper Extremities.
Medicina (Kaunas)
November 2024
Department of Replantation and Reconstruction, Centre of Postgraduate Medical Education, Professor A. Gruca Teaching Hospital, Konarskiego 13, 05-400 Otwock, Poland.
Successful treatment of severe trauma and fractures of the long bones with successful healing and bone union is still a significant challenge for surgeons. Unfortunately, up to 10% of long-bone fractures develop bone healing disorders. The aim of this study was to evaluate the results of treating bone defects with different etiologies in the upper and lower extremities using the induced membrane technique.
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