[Genomic, proteomic and metabolomic predictors of atherosclerosis in obese patients. Part II].

Currently there is no extensive research of metabolic disorders in obese patients with atherosclerosis, including the study of genomic, biochemical, immune and other markers. Therefore, the aim of the study was to identify the genomic, proteomic and metabolic predictors of atherosclerosis in obese patients. We evaluated condition of the cardiovascular system of the 100 obese patients aged 18 to 66 years, which were divided in two groups of patients: Group 1 consisted of 50 obese patients without vascular pathology, 2nd group consisted of 50 patients with obesity, complicated by atherosclerosis. We carried out a study of the lipid metabolism and analysis of polymorphic alleles ε2, ε3, ε4 of the ApoE gene by PCR. Our data showed that clinically significant predictors of atherosclerosis in obese patients are homozygous genotypes ε2/ε2 of the ApoE gene, increased blood serum level of triglycerides, oxidated LDL, interleukin-6, adhesion molecules SICAM, L-FABP and adiponectin reduction.