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Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles. | LitMetric

AI Article Synopsis

  • - The study investigates the molecular changes in the pancreas following a single episode of pancreatitis, noting that recovery happens quickly but the underlying gene expression changes are not well understood.
  • - Using a caerulein hyperstimulation model, researchers conducted RNA-sequencing to identify differentially expressed genes (DEGs) during the pancreas's recovery, revealing 319 DEGs at one week and 53 at two weeks post-injury.
  • - Notably, 40 DEGs remained elevated from the first to the second week, including various trypsinogen genes, indicating ongoing recovery processes and suggesting the presence of a novel transcriptome during pancreatic healing.

Article Abstract

It is well known that pancreatic recovery after a single episode of injury such as an isolated bout of pancreatitis occurs rapidly. It is unclear, however, what changes are inflicted in such conditions to the molecular landscape of the pancreas. In the caerulein hyperstimulation model of pancreatitis, the murine pancreas has the ability to recover within one week based on histological appearance. In this study, we sought to characterize by RNA-sequencing (RNA-seq) the transcriptional profile of the recovering pancreas up to two weeks post-injury. We found that one week after injury there were 319 differentially expressed genes (DEGs) compared with baseline and that after two weeks there were 53 DEGs. Forty (12.5%) of the DEGs persisted from week one to week two, and another 13 DEGs newly emerged in the second week. Amongst the top up-regulated DEGs were several trypsinogen genes (trypsinogen 4, 5, 12, 15, and 16). To our knowledge, this is the first characterization of the transcriptome during pancreatic recovery by deep sequencing, and it reveals on a molecular basis that there is an ongoing recovery of the pancreas even after apparent histological resolution. The findings also raise the possibility of an emerging novel transcriptome upon pancreatic recovery.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780441PMC
http://dx.doi.org/10.1038/s41598-018-19392-0DOI Listing

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