We report here that the expression of the transcription factor T-bet, which is known to be required for effector cytotoxic CD8 T lymphocytes (CTL) generation and effector memory cell formation, is regulated in CTL by microRNA-155 (miR-155). Importantly, we show that the proliferative effect of miR-155 on CD8 T cells is mediated by T-bet. T-bet levels in CTL were controlled by miR-155 SH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet. Our studies reveal an important and unexpected signaling axis between miR-155, T-bet, and SHIP-1 in CTL responses and suggest an important signaling module that regulates effector CTL immunity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765282 | PMC |
| http://dx.doi.org/10.3389/fimmu.2017.01696 | DOI Listing |
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