By analyzing a case of total knee arthroplasty (TKA) in a knee with complex deformity and secondary osteoarthritis, we demonstrated the rationale of preoperative planning and the detail of intraoperative execution. The lady had right TKA with combined medial closing wedge femoral osteotomy, neutral wedge valgus derotational tibial osteotomy, fibular osteotomy, and quadriceplasty. Four months later, she had left TKA. Osteotomies healed well and she was pain-free at 18 months after right TKA. Combination of intra-articular and extra-articular correction of deformity was the key to achieve a well-aligned TKA with good soft tissue balancing in both coronal and sagittal planes. The choice of osteotomy fixation method should follow the principles of bone healing. Fibular osteotomy should have been made at the level of tibial osteotomy with caution. Use of appropriate TKA prosthesis could have enhanced the osteotomy fixation while decreasing the complication.
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