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Effects of psychoplastogens on blood levels of brain-derived neurotrophic factor (BDNF) in humans: a systematic review and meta-analysis.
Mol Psychiatry
November 2024
Molecular Psychiatry Lab, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Article Synopsis
- A meta-analysis was conducted to evaluate whether psychoplastogens like ketamine and psychedelics increase peripheral BDNF levels in humans, which have been suggested as biomarkers for neuroplasticity.
- The analysis included data from 29 studies and found no significant evidence that these substances elevate peripheral BDNF levels, regardless of various factors such as drug type, dosage, or participant characteristics.
- The findings imply that peripheral BDNF may not be a reliable marker for assessing neuroplasticity changes in humans after psychoplastogen administration, highlighting potential discrepancies between preclinical and human studies.
Co-use of psychedelics with other substances: Findings from the global psychedelic survey.
J Psychopharmacol
October 2024
Michigan Psychedelic Center, University of Michigan, Ann Arbor, MI, USA.
Background/aims: While most psychedelic substances are considered to carry a relatively low risk of acute or long-term harm, co-use with other psychoactive substances may increase health and social harm. Using a large international survey of adults who use psychedelics, we sought to comprehensively characterize psychedelic co-use.
Methods: We used data from the 2023 Global Psychedelic Survey, a web-based survey of adults ⩾21 with lifetime use of psychedelics.
Inhaled Dimethyltryptamine (DMT): Use Patterns and Predictors of Consumption Frequency.
J Psychoactive Drugs
October 2024
Department of Psychology, University at Albany, State University of New York, Albany, NY, USA.
Article Synopsis
- - Despite growing interest in psychedelics, research on inhaled DMT is limited; a study with nearly 400 participants highlighted motivations for use, sources, and risk perceptions surrounding inhaled DMT.
- - Most users reported beginning their DMT journey out of curiosity or interest in psychedelics, often acquiring DMT through friends and using it alone or in small groups, with glass pipes being the preferred method of inhalation.
- - While many users described positive psychological experiences from inhaling DMT, they also faced challenges like difficult integration and "bad trips," emphasizing the need for more research and education on its safe use and potential benefits.
Drug-induced psychosis following use of Ayahuasca: a presentation to forensic psychiatric services.
BMJ Case Rep
August 2024
Royal Edinburgh Hospital, Edinburgh, UK
Ayahuasca is a plant-based psychoactive decoction, traditionally used by indigenous Amazonian peoples, which commonly contains the hallucinogen N,N-dimethyltryptamine (DMT). There is now growing interest across the Western world in psychedelics including Ayahuasca.This case describes a previously well male with no risk factors for adverse psychiatric outcomes or forensic history.
View Article and Find Full Text PDFGiving Voice to Women with Substance Use Disorder: Findings from Expressive Writing About Trauma.
Womens Health Rep (New Rochelle)
March 2024
Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA.
Background: Trauma exposure is a risk factor for substance use disorders (SUD) among women. This study explores written content from an expressive writing (EW) intervention conducted within a residential SUD program to examine themes across trauma experiences and characterize their deep insight into such experiences.
Materials And Methods: This qualitative study is a secondary data analysis of written content of the first writing session from women ( = 44) randomized to an EW condition while in residential SUD treatment.
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