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| http://dx.doi.org/10.18632/aging.101372 | DOI Listing |
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Integrative Analysis of Chromatin Accessibility and Transcriptional Landscape Identifies Key Genes During Muscle Development in Pigs.
Cells
December 2024
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Many efforts have been made to reveal the mechanisms underlying skeletal muscle development because of its importance in animals. However, knowledge on chromatin accessibility, a prerequisite for gene expression, remains limited. Here, dynamic changes in chromatin accessibility were analyzed in the skeletal muscles of Min pigs at the ages of 30, 90, and 210 d using an assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq).
View Article and Find Full Text PDFMachine learning-based selection of immune cell markers in osteosarcoma: prognostic determination and validation of CLK1 in disease progression.
Front Immunol
January 2025
Department of Pathology, Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China.
Introduction: Osteosarcoma (OS) is a malignancy of the bone that mainly afflicts younger individuals. Despite existing treatment approaches, patients with metastatic or recurrent disease generally face poor prognoses. A greater understanding of the tumor microenvironment (TME) is critical for enhancing outcomes in OS patients.
View Article and Find Full Text PDFDruggable genes for therapeutic targeting in PTH signaling for osteoporosis.
Expert Opin Ther Targets
December 2024
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Science, Tokyo University of Science, Noda, Chiba, Japan.
A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration.
Cell Stem Cell
December 2024
State Key Laboratory of Organ Failure Research, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China; Academy of Orthopedics, Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China. Electronic address:
Article Synopsis
- This study focuses on improving cartilage regeneration using stem cells by addressing issues like off-target differentiation and hypertrophic tendencies.
- Researchers created a system to monitor chondrogenesis and hypertrophy in real-time using stem cells with specific genetic markers and tested over 2,000 FDA-approved drugs.
- They discovered that the drug phentolamine promoted cartilage growth and avoided degeneration, suggesting the α2-AR/SLPI pathway as a potential target for effective cartilage regeneration.
Antipolyphosphate monoclonal antibodies derived from autoimmune mice.
Res Pract Thromb Haemost
August 2024
Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Background: Inorganic polyphosphates (polyPs) are linear chains of phosphates that accelerate blood clotting. Targeting polyP has been shown to reduce thrombosis.
Objectives: To identify and characterize anti-polyP monoclonal antibodies that could be used as analytical tools and as antithrombotic agents.
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