AI Article Synopsis
- The study investigates the link between specific chromosome 1p13 variants and the risk of developing peripheral artery disease (PAD) in Chinese patients with type 2 diabetes.
- It analyzes the genetic polymorphisms rs599839, rs646776, and rs12740374 in a group of 882 diabetes patients, finding lower frequencies of certain alleles and genotypes in those with PAD compared to those without.
- The results suggest that these genetic variations may serve as protective factors against PAD in this population, indicating a potential genetic influence on disease susceptibility.
Article Abstract
Aims/introduction: Variants on chromosome 1p13 have been associated with coronary artery disease and acute myocardial infarction risk in different ethnic groups. The present study aimed to investigate the association between 1p13 polymorphisms and the development of peripheral artery disease (PAD) in a Chinese population with type 2 diabetes mellitus.
Materials And Methods: 1p13 polymorphisms, rs599839, rs646776 and rs12740374, were assessed in a cohort of 882 type 2 diabetes mellitus patients including 440 type 2 diabetes mellitus patients with PAD (DM + PAD group) and 442 patients without PAD (DM group). Genotyping was carried out using TaqMan assay.
Results: Compared with the DM group, the frequencies of the minor G allele of both rs599839 and rs646776 and the minor T allele of rs12740374 decreased (P = 0.013, P = 0.019 and P = 0.005, respectively), and the frequencies of rs599839 AG + GG, rs646776 AG + GG and rs12740374 CT+TT genotypes were statistically significantly decreased as well (P = 0.017, P = 0.011 and P = 0.007, respectively) in the dominant model in the DM + PAD group than in the DM group. Multivariate unconditional logistic regression analyses adjusted for age, glycated hemoglobin, triglyceride, low-density lipoprotein cholesterol, smoking, hypertension, diabetes duration, coronary heart disease and cerebral infarction showed that the genotypic distribution of rs599839 AG + GG, rs646776 AG + GG and rs12740374 CT + TT remained statistically different between the DM and DM + PAD group (P = 0.014, P = 0.003 and P = 0.004, respectively). The frequencies of haplotype GGT were statistically significantly different between groups (P = 0.08).
Conclusions: The present study strongly supports that genotypes of rs599839, rs646776 and rs12740374 on 1p13 are protective factors for diabetic PAD in a Chinese population. Haplotype GGT generated by rs599839, rs646776 and rs12740374 might also decrease the risk of the disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123029 | PMC |
| http://dx.doi.org/10.1111/jdi.12804 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between Genetic Variants of and Cardiovascular Diseases: A Systematic Review and Meta-Analysis.
J Cardiovasc Dev Dis
February 2023
Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México 14080, Mexico.
A cluster of three genes , , and has been associated with cardiovascular diseases. Thus, the aim of this study was (i) to perform a systematic review and updated meta-analysis of the association of three polymorphisms (rs646776, rs599839, and rs464218) of this cluster with cardiovascular diseases, and (ii) to explore by PheWAS signals of the three SNPs in cardiovascular diseases and to evaluate the effect of rs599839 with tissue expression by in silico tools. Three electronic databases were searched to identify eligible studies.
View Article and Find Full Text PDFThe Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2 Trimester Lipid Levels and Preterm Birth.
Front Genet
June 2019
Department of Epidemiology, The University of Iowa, Iowa City, IA, United States.
Deregulation of the circadian system in humans and animals can lead to various adverse reproductive outcomes due to genetic mutations and environmental factors. In addition to the clock, lipid metabolism may also play an important role in influencing reproductive outcomes. Despite the importance of the circadian clock and lipid metabolism in regulating birth timing few studies have examined the relationship between circadian genetics with lipid levels during pregnancy and their relationship with preterm birth (PTB).
View Article and Find Full Text PDFAssociation between 1p13 polymorphisms and peripheral arterial disease in a Chinese population with diabetes.
J Diabetes Investig
September 2018
Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, China.
Article Synopsis
- The study investigates the link between specific chromosome 1p13 variants and the risk of developing peripheral artery disease (PAD) in Chinese patients with type 2 diabetes.
- It analyzes the genetic polymorphisms rs599839, rs646776, and rs12740374 in a group of 882 diabetes patients, finding lower frequencies of certain alleles and genotypes in those with PAD compared to those without.
- The results suggest that these genetic variations may serve as protective factors against PAD in this population, indicating a potential genetic influence on disease susceptibility.
A meta-analysis of three identified single nucleotide polymorphisms at 1p13.3 and 1q41 and their associations with lipid levels and coronary artery disease.
Kaohsiung J Med Sci
January 2017
Department of Encephalopathy Division I, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi, People's Republic of China. Electronic address:
The aim of this meta-analysis was to detect whether three identified single nucleotide polymorphisms (SNPs) (rs646776, rs599839, and rs17465637) at 1p13.3 and 1q41 are associated with lipid levels and the risk of coronary artery disease (CAD). Databases of MEDLINE, EMBASE, the Cochrane Library, and BIOSIS were systematically searched.
View Article and Find Full Text PDFAssociation between 1p13.3 genomic markers and coronary artery disease: a meta-analysis involving patients and controls.
Genet Mol Res
August 2015
Beijing Municipal Key Laboratory of Clinical Epidemiology, Youanmen, Beijing, China.
Recently, genome-wide association studies on cardio-vascular disease identified a series of associated single nucleotide polymorphisms in an intergenic region of chromosome 1p13.3. We investigated the association of this locus with cardiovascular disease in 13 case-control studies and undertook a meta-analysis for effect size, heterogeneity, publication bias, and strength of evidence.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!