AI Article Synopsis
- * The structures and configurations of these compounds were determined using spectroscopy and quantum chemistry.
- * The compounds were evaluated for their effects on cell growth inhibition and antibacterial properties.
Article Abstract
Five pairs of new 2-oxoindole alkaloids, (±)-peganumalines A-E (1-5), and a new indole alkaloid, peganumaline F (6), along with two known analogues, were isolated from the seeds of Peganum harmala. Their structures and absolute configurations were elucidated through spectroscopic analyses and quantum chemistry calculations. Notably, (±)-peganumalines A (1) represent a pair of rare 2-oxoindole dimeric alkaloid enantiomer with the hitherto unknown carbon skeleton. All isolates were tested for antiproliferative and antibacterial activities.
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| http://dx.doi.org/10.1016/j.fitote.2018.01.008 | DOI Listing |
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